Compound Detail
CHEMBL1676
FLUTICASONE FUROATE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)SCF
Basic Information
| ChEMBL ID | CHEMBL1676 |
| Name | FLUTICASONE FUROATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XTULMSXFIHGYFS-VLSRWLAYSA-N |
| Therapeutic | ✓ Yes |
7
Targets
11
Activities
3
Assay Types
7
PK Parameters
20
Publications
21
Known Names
10
Indications
1
Mechanisms
Molecular Properties
538.6
MW (Da)
4.93
ALogP
7
HBA
1
HBD
93.8
PSA (Ų)
0.54
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2007 |
| Availability | OTC |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Glucocorticoid receptor agonist | AGONIST | Glucocorticoid receptor | ✓ | ✓ |
Indications
Asthma Lung Diseases, Obstructive Nasal Obstruction Pulmonary Disease, Chronic Obstructive Rhinitis, Allergic, Perennial Rhinitis, Allergic, Seasonal Rhinitis, Allergic, Seasonal Rhinitis Rhinitis, Vasomotor Severe Acute Respiratory Syndrome
ATC Classification
R01AD12
fluticasone furoate
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
R03BA09
fluticasone furoate
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Activity Summary
IC50 8 meas. best 10.4
EC50 2 meas. best 9.4
Ki 1 meas. best 9.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 10.4 | 9.75 | 0.0 | 2 |
| PBMC CHEMBL613107 | IC50 | 10.3 | 10.3 | 0.1 | 1 |
| RAW264.7 CHEMBL612557 | IC50 | 10.0 | 10.0 | 0.1 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 9.4 | 9.355 | 0.4 | 2 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 9.29 | 9.29 | 0.5 | 1 |
| Progesterone receptor CHEMBL208 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
| Blood CHEMBL613416 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
| Mineralocorticoid receptor CHEMBL1994 | IC50 | 6.78 | 6.78 | 166.0 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 5.73 | 5.73 | 1880.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUClast | 0.05 | hr.nmol/ml | Rattus norvegicus |
| AUClast | 1049.0 | hr.nmol/g | Rattus norvegicus |
| Cmax | 45.0 | nM | Rattus norvegicus |
| Cmax | 77.1 | nmol/g | Rattus norvegicus |
| F | 1.6 | % | Homo sapiens |
| T1/2 | 15.3 | hr | Homo sapiens |
| Vd | 642.0 | l | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine