Assay Detail
Binding
CHEMBL4189815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of nuclear translocation of human recombinant ProLabel-tagged glucocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminescence method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Pyrrolidine Derivatives of Budesonide as Long Acting Inhaled Corticosteroids for the Treatment of Pulmonary Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 8.05 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1676 | FLUTICASONE FUROATE | 4.0 | 1 | 9.40 |
| CHEMBL4205561 | — | — | 1 | 8.89 |
| CHEMBL4204358 | — | — | 1 | 8.89 |
| CHEMBL4204087 | — | — | 1 | 8.77 |
| CHEMBL4204230 | — | — | 1 | 8.74 |
| CHEMBL4217175 | — | — | 1 | 8.68 |
| CHEMBL4214152 | — | — | 1 | 8.49 |
| CHEMBL4202463 | — | — | 1 | 8.47 |
| CHEMBL4202533 | — | — | 1 | 8.47 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 8.46 |
| CHEMBL4208840 | — | — | 1 | 8.34 |
| CHEMBL4211724 | — | — | 1 | 8.28 |
| CHEMBL4215262 | — | — | 1 | 8.24 |
| CHEMBL4216231 | — | — | 1 | 8.24 |
| CHEMBL4203139 | — | — | 1 | 8.13 |
| CHEMBL4203448 | — | — | 1 | 8.11 |
| CHEMBL4208957 | — | — | 1 | 8.08 |
| CHEMBL4211166 | — | — | 1 | 8.07 |
| CHEMBL4206713 | — | — | 1 | 7.95 |
| CHEMBL4211798 | — | — | 1 | 7.82 |
| CHEMBL4217173 | — | — | 1 | 7.68 |
| CHEMBL4213765 | — | — | 1 | 7.51 |
| CHEMBL4217942 | — | — | 1 | 7.39 |
| CHEMBL4202674 | — | — | 1 | 7.36 |
| CHEMBL4213791 | — | — | 1 | 7.35 |
| CHEMBL4218553 | — | — | 1 | 7.30 |
| CHEMBL4212517 | — | — | 1 | 7.26 |
| CHEMBL4214377 | — | — | 1 | 7.24 |
| CHEMBL4217464 | — | — | 1 | 7.19 |
| CHEMBL4216014 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1676 | FLUTICASONE FUROATE | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4205561 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4204358 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4204087 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4204230 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4217175 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4214152 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4202463 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4202533 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1370 | BUDESONIDE | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4208840 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4211724 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4215262 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4216231 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4203139 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4203448 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4208957 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4211166 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4206713 | — | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL4211798 | — | EC50 | = | 15.2 | nM | 7.82 |
| CHEMBL4217173 | — | EC50 | = | 20.8 | nM | 7.68 |
| CHEMBL4213765 | — | EC50 | = | 31.2 | nM | 7.51 |
| CHEMBL4217942 | — | EC50 | = | 40.3 | nM | 7.39 |
| CHEMBL4202674 | — | EC50 | = | 44.1 | nM | 7.36 |
| CHEMBL4213791 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4218553 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4212517 | — | EC50 | = | 54.9 | nM | 7.26 |
| CHEMBL4214377 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4217464 | — | EC50 | = | 63.9 | nM | 7.19 |
| CHEMBL4216014 | — | EC50 | = | 248.0 | nM | 6.61 |
| CHEMBL4210515 | — | EC50 | - | — | - |