Compound Detail
CHEMBL4202463
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)CCN1C[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)C1
Basic Information
| ChEMBL ID | CHEMBL4202463 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XNOWUQCQAPUSJT-OOXXBYQCSA-N |
2
Targets
3
Activities
3
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
491.6
MW (Da)
3.44
ALogP
5
HBA
2
HBD
77.8
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.47
IC50 1 meas. best 9.66
Ki 1 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW264.7 CHEMBL612557 | IC50 | 9.66 | 9.66 | 0.2 | 1 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 8.72 | 8.72 | 1.9 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 8.47 | 8.47 | 3.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | IC50 | = | 0.22 | nM | 9.66 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-... | 29741897 |
| Glucocorticoid receptor | Ki | = | 1.9 | nM | 8.72 | Displacement of [3H]dexamethasone from human recombinant glucocorticoid receptor... | 29741897 |
| Glucocorticoid receptor | EC50 | = | 3.4 | nM | 8.47 | Induction of nuclear translocation of human recombinant ProLabel-tagged glucocor... | 29741897 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29741897 | 10.1021/acs.jmedchem.7b01873 | Glucocorticoid receptor | 2 |
| 29741897 | 10.1021/acs.jmedchem.7b01873 | No relevant target | 1 |
| 29741897 | 10.1021/acs.jmedchem.7b01873 | RAW264.7 | 1 |
Data from ChEMBL 36 via Core Engine