Assay Detail
Functional
CHEMBL4189819
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release preincubated for 15 mins followed by LPS challenge measured after 18 hrs by Griess assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel Pyrrolidine Derivatives of Budesonide as Long Acting Inhaled Corticosteroids for the Treatment of Pulmonary Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 9.34 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204230 | — | — | 1 | 10.10 |
| CHEMBL1676 | FLUTICASONE FUROATE | 4.0 | 1 | 10.00 |
| CHEMBL4204087 | — | — | 1 | 9.82 |
| CHEMBL4208957 | — | — | 1 | 9.80 |
| CHEMBL4202463 | — | — | 1 | 9.66 |
| CHEMBL4205561 | — | — | 1 | 9.60 |
| CHEMBL4211724 | — | — | 1 | 9.52 |
| CHEMBL4206713 | — | — | 1 | 9.52 |
| CHEMBL4208840 | — | — | 1 | 9.48 |
| CHEMBL4204358 | — | — | 1 | 9.47 |
| CHEMBL4216231 | — | — | 1 | 9.40 |
| CHEMBL4217175 | — | — | 1 | 9.36 |
| CHEMBL4211166 | — | — | 1 | 9.18 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 9.09 |
| CHEMBL4214152 | — | — | 1 | 8.86 |
| CHEMBL4203448 | — | — | 1 | 8.85 |
| CHEMBL4203139 | — | — | 1 | 8.43 |
| CHEMBL4213765 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204230 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1676 | FLUTICASONE FUROATE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4204087 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4208957 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL4202463 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4205561 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4211724 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4206713 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4208840 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL4204358 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4216231 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4217175 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4211166 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL4214152 | — | IC50 | = | 1.38 | nM | 8.86 |
| CHEMBL4203448 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4203139 | — | IC50 | = | 3.68 | nM | 8.43 |
| CHEMBL4213765 | — | IC50 | = | 11.9 | nM | 7.92 |