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Target Snapshot

CHEMBL612557 Target Snapshot

RAW264.7 · CELL-LINE · Mus musculus

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14,020Compounds
5,616Assays
34Approved Drugs
9,287.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats RAW264.7 as ChEMBL target CHEMBL612557. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
RAW264.7
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL612557
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether RAW264.7 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameRAW264.7
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRAW264.7
UniProt AccessionN/A

RAW264.7

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as RAW264.7.

Review nameRAW264.7
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

34
Approved
17
Phase III
26
Phase II
7
Phase I
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC509,093.0
EC50194.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5072364 10.97 IC50 0.0107 Preclinical
CHEMBL5089388 10.94 IC50 0.0116 Preclinical
CHEMBL3329998 10.85 IC50 0.014 Preclinical
CHEMBL5075905 10.77 IC50 0.0168 Preclinical
CHEMBL5083589 10.74 IC50 0.0182 Preclinical
CHEMBL5090950 10.44 IC50 0.036 Preclinical
CHEMBL5087366 10.4 IC50 0.0401 Preclinical
CHEMBL408513 10.23 IC50 0.059 Approved
CHEMBL4204230 10.1 IC50 0.08 Preclinical
CHEMBL1676 10.0 IC50 0.1 Approved
Distribution

pChEMBL Value Distribution

1314
5.0
694
5.5
381
6.0
184
6.5
111
7.0
53
7.5
48
8.0
20
8.5
12
9.0
9
9.5
pChEMBL
Approved Drugs

Approved Drugs

PEXIDARTINIB
CHEMBL3813873
Approved 2019
Properties Compare Identifier
BELINOSTAT
CHEMBL408513
Approved 2014
Properties Compare Identifier
FLUTICASONE FUROATE
CHEMBL1676
Approved 2007
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
CELECOXIB
CHEMBL118
Approved 1998
Properties Compare Identifier
ALENDRONATE SODIUM
CHEMBL675
Approved 1995
Properties Compare Identifier
BUDESONIDE
CHEMBL1370
Approved 1994
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
IBUPROFEN
CHEMBL521
Approved 1974
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
INDOMETHACIN
CHEMBL6
Approved 1965
Properties Compare Identifier
DEXAMETHASONE
CHEMBL384467
Approved 1958
Properties Compare Identifier
HYDROCORTISONE
CHEMBL389621
Approved 1952
Properties Compare Identifier
Assay Landscape

Assay Landscape

5,617
Total Assays
4,265
Tested Compounds
4
Assay Types
Functional — 4,420 assays, 4,265 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4,419 4,265 5.2
organism-based format 1 0 —
ADME — 906 assays, 628 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 906 628 4.8
Toxicity — 289 assays, 174 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 289 174 4.5
Unassigned — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine