Assay Detail
Binding
CHEMBL4031196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.95 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3666814 | — | — | 1 | 9.10 |
| CHEMBL1676 | FLUTICASONE FUROATE | 4.0 | 1 | 9.10 |
| CHEMBL4072756 | AZD-5423 | 2.0 | 1 | 9.05 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | 4.0 | 1 | 9.05 |
| CHEMBL3666807 | VELSECORAT | 2.0 | 1 | 9.05 |
| CHEMBL3666813 | — | — | 1 | 9.00 |
| CHEMBL3666805 | — | — | 1 | 8.82 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3666814 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1676 | FLUTICASONE FUROATE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4072756 | AZD-5423 | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3666807 | VELSECORAT | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3666813 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3666805 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 3.8 | nM | 8.42 |