Assay Detail
Functional
CHEMBL1838802
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Inhibition of TNFalpha release in human PBMC by ELISA assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 9.84 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834544 | — | — | 1 | 10.52 |
| CHEMBL1834538 | — | — | 1 | 10.40 |
| CHEMBL1676 | FLUTICASONE FUROATE | 4.0 | 1 | 10.30 |
| CHEMBL1834542 | — | — | 1 | 10.22 |
| CHEMBL1834534 | — | — | 1 | 10.05 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | 4.0 | 1 | 10.00 |
| CHEMBL1834537 | — | — | 1 | 10.00 |
| CHEMBL3142314 | — | — | 1 | 9.92 |
| CHEMBL1834543 | — | — | 1 | 9.82 |
| CHEMBL1834540 | — | — | 1 | 9.80 |
| CHEMBL1834533 | — | — | 1 | 9.77 |
| CHEMBL1834541 | — | — | 1 | 9.66 |
| CHEMBL1834535 | — | — | 1 | 9.39 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 9.02 |
| CHEMBL1834536 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834544 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL1834538 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1676 | FLUTICASONE FUROATE | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1834542 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1834534 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1834537 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3142314 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL1834543 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL1834540 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL1834533 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1834541 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL1834535 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL1834536 | — | IC50 | = | 1.81 | nM | 8.74 |