Assay Detail
Functional
CHEMBL1838803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha release in LPS-stimulated human whole blood by ELISA assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.77 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 8.07 |
| CHEMBL1834544 | — | — | 1 | 8.06 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | 4.0 | 1 | 8.03 |
| CHEMBL1676 | FLUTICASONE FUROATE | 4.0 | 1 | 7.37 |
| CHEMBL1834537 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1370 | BUDESONIDE | IC50 | = | 8.46 | nM | 8.07 |
| CHEMBL1834544 | — | IC50 | = | 8.73 | nM | 8.06 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL1676 | FLUTICASONE FUROATE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1834537 | — | IC50 | = | 47.4 | nM | 7.32 |