Assay Detail
Functional
CHEMBL1639147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | BESM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 54 | 5.12 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1714574 | TERCONAZOLE | 4.0 | 1 | 6.40 |
| CHEMBL1103 | FURAZOLIDONE | 4.0 | 1 | 6.40 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 6.40 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.10 |
| CHEMBL633 | AMIODARONE | 4.0 | 1 | 6.10 |
| CHEMBL639 | AZELASTINE | 4.0 | 1 | 6.00 |
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 5.52 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.52 |
| CHEMBL3215298 | ABAMECTIN | 3.0 | 1 | 5.40 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 5.40 |
| CHEMBL19215 | METERGOLINE | 2.0 | 1 | 5.40 |
| CHEMBL567 | PERPHENAZINE | 4.0 | 1 | 5.30 |
| CHEMBL115769 | — | — | 1 | 5.30 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | — | 1 | 5.30 |
| CHEMBL828 | PHENOTHIAZINE | 2.0 | 1 | 5.22 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.16 |
| CHEMBL1456 | MYCOPHENOLATE MOFETIL | 4.0 | 1 | 5.16 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.16 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 5.10 |
| CHEMBL1419 | SIBUTRAMINE | 4.0 | 1 | 5.10 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | 4.0 | 1 | 5.10 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 5.10 |
| CHEMBL623 | NEFAZODONE | 4.0 | 1 | 5.10 |
| CHEMBL869 | NITROFURAZONE | 4.0 | 1 | 5.10 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.05 |
| CHEMBL998 | LORATADINE | 4.0 | 1 | 5.05 |
| CHEMBL29188 | LOMERIZINE | 2.0 | 1 | 5.05 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 5.00 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.00 |
| CHEMBL142635 | NAFTOPIDIL | 4.0 | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1714574 | TERCONAZOLE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL123292 | CYCLOHEXIMIDE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1103 | FURAZOLIDONE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3545252 | DOCETAXEL | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL633 | AMIODARONE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL639 | AZELASTINE | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL841 | LOPERAMIDE | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL275040 | KAINIC ACID | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3215298 | ABAMECTIN | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL19215 | METERGOLINE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL726 | FLUPHENAZINE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL567 | PERPHENAZINE | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL115769 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL828 | PHENOTHIAZINE | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL54 | HALOPERIDOL | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL41 | FLUOXETINE | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1456 | MYCOPHENOLATE MOFETIL | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL723 | CARVEDILOL | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1419 | SIBUTRAMINE | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL415 | CLOMIPRAMINE | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL623 | NEFAZODONE | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL869 | NITROFURAZONE | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL29188 | LOMERIZINE | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL998 | LORATADINE | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL941 | IMATINIB | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL81 | RALOXIFENE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL553025 | VINORELBINE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL142635 | NAFTOPIDIL | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1172 | DESLORATADINE | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1515447 | HOMOCHLORCYCLIZINE | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL707 | DOXAZOSIN | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2 | PRAZOSIN | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL629 | AMITRIPTYLINE | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL564 | PROMAZINE | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL444463 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1630579 | MYRTECAINE | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL485549 | NIFURSOL | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1200478 | DYCLONINE HYDROCHLORIDE | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1365675 | AMITRAZ | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL141343 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1201146 | NORETHINDRONE ACETATE | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1201203 | BENZTROPINE | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1618305 | NALOXONAZINE | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL34139 | GENACONAZOLE | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1385840 | ERGOCORNINE | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL95 | TACRINE | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1159650 | CLOBETASOL PROPIONATE | EC50 | = | 25000.0 | nM | 4.60 |