Compound Detail
CHEMBL1419
SIBUTRAMINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1419 |
| Name | SIBUTRAMINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | UNAANXDKBXWMLN-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
7
Targets
14
Activities
3
Assay Types
0
PK Parameters
20
Publications
7
Known Names
1
Indications
Molecular Properties
279.9
MW (Da)
4.74
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.75
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1997 |
| Availability | Withdrawn |
| Chirality | Racemic |
Indications
Obesity
ATC Classification
A08AA10
sibutramine
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Drug Warnings
Withdrawn
neurotoxicity
Increased risk of heart attack and stroke
Withdrawn
cardiotoxicity
Higher rate of cardiovascular events in obese and overweight patients using sibutramine than in patients managing their weight through exercise and diet alone
Withdrawn
cardiotoxicity
Increased risk of heart attack and stroke
Withdrawn
cardiotoxicity
Increase of risk of cardivascular events in patients with history of cardiovascular disease; Based on data from the SCOUT trial (which showed a higher rate of cardiovascular events in obese and overwe...
Withdrawn
cardiotoxicity
Increased risk of heart attack and stroke
Activity Summary
IC50 6 meas. best 6.2
Ki 6 meas. best 6.3
EC50 2 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 6.3 | 6.3 | 502.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 6.2 | 6.2 | 632.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 6.14 | 5.86 | 719.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 6.09 | 5.83 | 809.0 | 2 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 5.96 | 5.96 | 1091.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 5.96 | 5.96 | 1108.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 5.68 | 5.68 | 2085.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | IC50 | 5.62 | 5.62 | 2390.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 5.25 | 5.25 | 5665.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 5.25 | 5.25 | 5619.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 5.1 | 5.1 | 8000.0 | 1 |
| ADMET CHEMBL612558 | EC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine