Compound Detail
CHEMBL1103
FURAZOLIDONE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1103 |
| Name | FURAZOLIDONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | PLHJDBGFXBMTGZ-WEVVVXLNSA-N |
| Therapeutic | ✓ Yes |
4
Targets
15
Activities
2
Assay Types
0
PK Parameters
20
Publications
5
Known Names
1
Mechanisms
Molecular Properties
225.2
MW (Da)
0.97
ALogP
6
HBA
0
HBD
98.2
PSA (Ų)
0.43
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1958 |
| Availability | Discontinued |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| DNA inhibitor | INHIBITOR | DNA | ✓ | ✓ |
ATC Classification
G01AX06
furazolidone
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
Activity Summary
IC50 14 meas. best 6.55
EC50 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leishmania donovani CHEMBL367 | IC50 | 6.55 | 5.952 | 280.0 | 5 |
| Leishmania major CHEMBL612879 | IC50 | 6.47 | 5.8575 | 340.0 | 4 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 6.4 | 6.4 | 400.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 5.7 | 5.59 | 2010.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 4.87 | 4.6333 | 13354.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine