Assay Detail
Functional
CHEMBL5355754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania major IR-173 amastigote infected in human THP-1 cells assessed as static activity by measuring inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antileishmanial activity of alkylene-linked nitrofurantoin-triazole hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.88 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.52 |
| CHEMBL5415247 | — | — | 1 | 6.21 |
| CHEMBL5410890 | — | — | 1 | 6.08 |
| CHEMBL869 | NITROFURAZONE | 4.0 | 1 | 5.55 |
| CHEMBL5418015 | — | — | 1 | 5.48 |
| CHEMBL1103 | FURAZOLIDONE | 4.0 | 1 | 5.24 |
| CHEMBL351937 | — | — | 1 | 5.08 |
| CHEMBL5427780 | — | — | 1 | - |
| CHEMBL5432685 | — | — | 1 | - |
| CHEMBL5427246 | — | — | 1 | - |
| CHEMBL5420547 | — | — | 1 | - |
| CHEMBL5399650 | — | — | 1 | - |
| CHEMBL5418562 | — | — | 1 | - |
| CHEMBL5416629 | — | — | 1 | - |
| CHEMBL5422018 | — | — | 1 | - |
| CHEMBL5418010 | — | — | 1 | - |
| CHEMBL5404303 | — | — | 1 | - |
| CHEMBL5398253 | — | — | 1 | - |
| CHEMBL5427768 | — | — | 1 | - |
| CHEMBL5401416 | — | — | 1 | - |
| CHEMBL5433418 | — | — | 1 | - |
| CHEMBL5399777 | — | — | 1 | - |
| CHEMBL5427247 | — | — | 1 | - |
| CHEMBL5398135 | — | — | 1 | - |
| CHEMBL5425644 | — | — | 1 | - |
| CHEMBL5394943 | — | — | 1 | - |
| CHEMBL5422778 | — | — | 1 | - |
| CHEMBL5434534 | — | — | 1 | - |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | - |
| CHEMBL5400778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5415247 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5410890 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL869 | NITROFURAZONE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5418015 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL1103 | FURAZOLIDONE | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL351937 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL5420547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5435813 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5399650 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5418562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5416629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5422018 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5418010 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5404303 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5398253 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5432685 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5415078 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5407988 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5402237 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5427246 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5427780 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5427768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401416 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5433418 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5399777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5427247 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5398135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5425644 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5394943 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5422778 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5434534 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL572 | NITROFURANTOIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL5400778 | — | IC50 | > | 10000.0 | nM | - |