Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5355761

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani 9515 promastigotes assessed as inhibition of parasite growth incubated for 48 hrs by resazurin dye based assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Synthesis and in vitro antileishmanial activity of alkylene-linked nitrofurantoin-triazole hybrids.
Zuma NH, Aucamp J, Janse van Rensburg HD, N'Da DD.
Eur J Med Chem (2023) 246 : 115012 -115012
PubMed 36516584 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 6.60 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5422018 1 8.00
CHEMBL267345 AMPHOTERICIN B 4.0 1 7.70
CHEMBL5398135 1 7.30
CHEMBL5399777 1 7.22
CHEMBL5433418 1 6.96
CHEMBL5425644 1 6.64
CHEMBL1103 FURAZOLIDONE 4.0 1 6.55
CHEMBL5401416 1 6.32
CHEMBL5404303 1 6.21
CHEMBL5427247 1 6.01
CHEMBL5415078 1 5.92
CHEMBL869 NITROFURAZONE 4.0 1 5.73
CHEMBL5422778 1 5.27
CHEMBL5434534 1 -
CHEMBL572 NITROFURANTOIN 4.0 1 -
CHEMBL5398253 1 -
CHEMBL5418010 1 -
CHEMBL5410890 1 -
CHEMBL5432685 1 -
CHEMBL5415247 1 -
CHEMBL5427246 1 -
CHEMBL5418562 1 -
CHEMBL5399650 1 -
CHEMBL5420547 1 -
CHEMBL5400778 1 -
CHEMBL5427780 1 -
CHEMBL5427768 1 -
CHEMBL5416629 1 -
CHEMBL351937 1 -
CHEMBL5394943 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5422018 IC50 = 10.0 nM 8.00
CHEMBL267345 AMPHOTERICIN B IC50 = 20.0 nM 7.70
CHEMBL5398135 IC50 = 50.0 nM 7.30
CHEMBL5399777 IC50 = 60.0 nM 7.22
CHEMBL5433418 IC50 = 110.0 nM 6.96
CHEMBL5425644 IC50 = 230.0 nM 6.64
CHEMBL1103 FURAZOLIDONE IC50 = 280.0 nM 6.55
CHEMBL5401416 IC50 = 480.0 nM 6.32
CHEMBL5404303 IC50 = 610.0 nM 6.21
CHEMBL5427247 IC50 = 980.0 nM 6.01
CHEMBL5415078 IC50 = 1200.0 nM 5.92
CHEMBL869 NITROFURAZONE IC50 = 1850.0 nM 5.73
CHEMBL5422778 IC50 = 5350.0 nM 5.27
CHEMBL5407988 IC50 > 10000.0 nM -
CHEMBL5402237 IC50 > 10000.0 nM -
CHEMBL5435813 IC50 > 10000.0 nM -
CHEMBL5418015 IC50 > 10000.0 nM -
CHEMBL5434534 IC50 > 10000.0 nM -
CHEMBL572 NITROFURANTOIN IC50 > 10000.0 nM -
CHEMBL5398253 IC50 > 10000.0 nM -
CHEMBL5418010 IC50 > 10000.0 nM -
CHEMBL5410890 IC50 > 10000.0 nM -
CHEMBL5432685 IC50 > 10000.0 nM -
CHEMBL5415247 IC50 > 10000.0 nM -
CHEMBL5427246 IC50 > 10000.0 nM -
CHEMBL5418562 IC50 > 10000.0 nM -
CHEMBL5399650 IC50 > 10000.0 nM -
CHEMBL5420547 IC50 > 10000.0 nM -
CHEMBL5400778 IC50 > 10000.0 nM -
CHEMBL5427780 IC50 > 10000.0 nM -
CHEMBL5427768 IC50 > 10000.0 nM -
CHEMBL5416629 IC50 > 10000.0 nM -
CHEMBL351937 IC50 > 10000.0 nM -
CHEMBL5394943 IC50 > 10000.0 nM -