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Assay Detail

CHEMBL5330073

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani MHOM/IN/95/9515 amastigote assessed as inhibition of parasite growth incubated for 48 hrs by resazurin staining based analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Design, synthesis, electrochemistry and anti-trypanosomatid hit/lead identification of nitrofuranylazines.
Saayman M, Kannigadu C, Aucamp J, Janse van Rensburg HD, Joseph C, Swarts AJ, N'Da DD.
RSC Med Chem (2023) 14 : 2012 -2029
PubMed 37859713 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.83 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5423743 1 6.60
CHEMBL5433031 1 6.47
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.35
CHEMBL5425056 1 6.28
CHEMBL869 NITROFURAZONE 4.0 1 5.77
CHEMBL5396329 1 5.64
CHEMBL5419390 1 5.57
CHEMBL351937 1 5.57
CHEMBL1103 FURAZOLIDONE 4.0 1 5.57
CHEMBL5430637 1 5.19
CHEMBL5406125 1 5.14
CHEMBL5417965 1 -
CHEMBL5395967 1 -
CHEMBL4870182 1 -
CHEMBL5437595 1 -
CHEMBL5421631 1 -
CHEMBL5417680 1 -
CHEMBL5429955 1 -
CHEMBL5418513 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5423743 IC50 = 250.0 nM 6.60
CHEMBL5433031 IC50 = 340.0 nM 6.47
CHEMBL267345 AMPHOTERICIN B IC50 = 450.0 nM 6.35
CHEMBL5425056 IC50 = 530.0 nM 6.28
CHEMBL869 NITROFURAZONE IC50 = 1690.0 nM 5.77
CHEMBL5396329 IC50 = 2280.0 nM 5.64
CHEMBL5419390 IC50 = 2700.0 nM 5.57
CHEMBL351937 IC50 = 2680.0 nM 5.57
CHEMBL1103 FURAZOLIDONE IC50 = 2700.0 nM 5.57
CHEMBL5430637 IC50 = 6410.0 nM 5.19
CHEMBL5406125 IC50 = 7260.0 nM 5.14
CHEMBL5417965 IC50 > 10000.0 nM -
CHEMBL5395967 IC50 > 10000.0 nM -
CHEMBL4870182 IC50 > 10000.0 nM -
CHEMBL5437595 IC50 > 10000.0 nM -
CHEMBL5421631 IC50 > 10000.0 nM -
CHEMBL5417680 IC50 > 10000.0 nM -
CHEMBL5429955 IC50 > 10000.0 nM -
CHEMBL5418513 IC50 > 10000.0 nM -