Androgen receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Androgen receptor shows approved-linked disease relevance led by prostate cancer. 5 more disease programs remain visible in the same review block. 19 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P10275. Start with prostate cancer, then reuse UniProt P10275 as the stable protein anchor across project notes and exports.
Start with prostate cancer, then reuse UniProt P10275 as the stable protein anchor across project notes and exports.
Androgen receptor shows approved-linked disease relevance led by prostate cancer. 5 more disease programs remain visible in the same review block. 19 linked drugs remain visible in the same block.
Start review with prostate cancer because it currently carries approved-linked support. Linked drugs include ABIRATERONE, APALUTAMIDE, APC-100, AZD3514. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAndrogen receptor
Review this target as Androgen receptor, mapped to UniProt P10275. Sequence length is 920 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Androgen receptor as ChEMBL target CHEMBL1871, mapped to UniProt P10275. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Androgen receptor is the right protein anchor across sources, using UniProt P10275 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why prostate cancer is currently framed as approved-linked support. It currently carries 19 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Androgen receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P10275 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Androgen receptor |
| UniProt Accession | P10275 |
| Component Type | Protein |
| Sequence Length | 920 aa |
Androgen receptor
Review this target as Androgen receptor, mapped to UniProt P10275. Sequence length is 920 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Androgen receptor shows approved-linked disease relevance led by prostate cancer. 5 more disease programs remain visible in the same review block.
Start review with prostate cancer because it currently carries approved-linked support. Linked drugs include ABIRATERONE, APALUTAMIDE, APC-100, AZD3514. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL180681 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL166444 | 10.89 | EC50 | 0.013 | Clinical |
| CHEMBL391548 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL3818706 | 10.5 | EC50 | 0.03162 | Preclinical |
| CHEMBL3238292 | 10.41 | EC50 | 0.039 | Preclinical |
| CHEMBL3765171 | 10.4 | EC50 | 0.0398 | Preclinical |
| CHEMBL27769 | 10.3 | EC50 | 0.05 | Clinical |
| CHEMBL27769 | 10.3 | IC50 | 0.05 | Clinical |
| CHEMBL3238291 | 10.22 | EC50 | 0.06 | Preclinical |
| CHEMBL3238288 | 10.13 | EC50 | 0.074 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 768 | 1,784 | 6.8 |
| single protein format | 332 | 889 | 6.8 |
| assay format | 47 | 224 | 6.5 |
| tissue-based format | 9 | 23 | 6.4 |
| cell membrane format | 1 | 9 | 8.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 261 | 755 | 6.9 |
| assay format | 69 | 153 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 27 | 37 | 7.3 |
| single protein format | 6 | 3 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |