Compound Detail
CHEMBL1170
TESTOSTERONE PROPIONATE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Basic Information
| ChEMBL ID | CHEMBL1170 |
| Name | TESTOSTERONE PROPIONATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | PDMMFKSKQVNJMI-BLQWBTBKSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL386630 |
4
Targets
5
Activities
3
Assay Types
3
PK Parameters
20
Publications
9
Known Names
1
Indications
1
Mechanisms
Molecular Properties
344.5
MW (Da)
4.84
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1974 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Androgen Receptor agonist | AGONIST | Androgen receptor | ✓ | ✓ |
Indications
Atrophic Vaginitis
Activity Summary
IC50 3 meas. best 7.75
EC50 1 meas. best 8.55
Ki 1 meas. best 9.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Androgen receptor CHEMBL1871 | Ki | 9.6 | 9.6 | 0.2 | 1 |
| Androgen receptor CHEMBL3056 | EC50 | 8.55 | 8.55 | 2.8 | 1 |
| Androgen receptor CHEMBL1871 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase CHEMBL3522 | IC50 | 7.25 | 7.25 | 56.0 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 5.72 | 5.72 | 1905.5 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | - | - | Rattus norvegicus |
| AUC | 2.5 | ng/ml | Rattus norvegicus |
| Cmax | - | - | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Androgen receptor | Ki | = | 0.25 | nM | 9.6 | Displacement of [3H]DHT from human androgen receptor in MDA453 cells | 17574413 |
| Androgen receptor | EC50 | = | 2.8 | nM | 8.55 | Agonist activity at androgen receptor in mouse C2C12 cells by receptor transacti... | 17574413 |
| Androgen receptor | IC50 | = | 18.0 | nM | 7.75 | Displacement of [3H]mibolerone from human AR expressed in COS cells after 3.5 hr... | - |
| Steroid 17-alpha-hydroxylase/17,20 lyase | IC50 | = | 56.0 | nM | 7.25 | In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid... | 12773039 |
| Androgen receptor | IC50 | = | 1905.46 | nM | 5.72 | Inhibitory concentration against recombinant rat androgen receptor expressed in ... | 16134935 |
Literature References
Data from ChEMBL 36 via Core Engine