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Target Snapshot

CHEMBL3056 Target Snapshot

Androgen receptor · SINGLE PROTEIN · Mus musculus

363Compounds
53Assays
6Approved Drugs
284.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P19091. Use UniProt P19091 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P19091 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Androgen receptor as ChEMBL target CHEMBL3056, mapped to UniProt P19091. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Androgen receptor
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL3056
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P19091
Androgen receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Androgen receptor is the right protein anchor across sources, using UniProt P19091 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAndrogen receptor
UniProt AccessionP19091
Component TypeProtein
Sequence Length899 aa

Androgen receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Androgen receptor, mapped to UniProt P19091. Sequence length is 899 aa.

Mapped IDP19091
Review nameAndrogen receptor
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

6
Approved
3
Phase II
Assay Mix

Activity Type Distribution

IC50244.0
KI1.0
EC5039.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL229264 9.36 EC50 0.44 Preclinical
CHEMBL3326454 9.3 EC50 0.5 Preclinical
CHEMBL3084681 9.0 EC50 1.0 Preclinical
CHEMBL27769 9.0 IC50 1.0 Clinical
CHEMBL386630 8.7 EC50 1.995 Approved
CHEMBL3084684 8.7 EC50 1.995 Preclinical
CHEMBL3084690 8.7 EC50 1.995 Preclinical
CHEMBL3084691 8.7 EC50 1.995 Preclinical
CHEMBL3084693 8.7 EC50 1.995 Preclinical
CHEMBL5169599 8.7 Ki 2.0 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
16
5.5
22
6.0
26
6.5
54
7.0
55
7.5
27
8.0
13
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

BICALUTAMIDE
CHEMBL409
Approved 1995
PROGESTERONE
CHEMBL103
Approved 1976
TESTOSTERONE PROPIONATE
CHEMBL1170
Approved 1974
TESTOSTERONE
CHEMBL386630
Approved 1972
MEDROXYPROGESTERONE ACETATE
CHEMBL717
Approved 1959
Assay Landscape

Assay Landscape

53
Total Assays
171
Tested Compounds
3
Assay Types
Binding — 26 assays, 171 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 51 6.3
single protein format 4 120 7.5
assay format 3 0
Functional — 25 assays, 54 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 10 0
organism-based format 8 0
cell-based format 6 39 7.3
assay format 1 15 6.8
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine