Assay Detail
Binding
CHEMBL661144
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escherichia coli or P450c17-LNCaP cells as the enzyme source.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LNCaP |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.16 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74661 | — | — | 1 | 7.30 |
| CHEMBL1170 | TESTOSTERONE PROPIONATE | 4.0 | 1 | 7.25 |
| CHEMBL310336 | — | — | 1 | 6.82 |
| CHEMBL77751 | NRB 03731 | — | 1 | 6.75 |
| CHEMBL305896 | — | — | 1 | 6.65 |
| CHEMBL75474 | — | — | 1 | 6.52 |
| CHEMBL2112282 | — | — | 1 | 6.50 |
| CHEMBL78108 | — | — | 1 | 6.42 |
| CHEMBL78003 | — | — | 1 | 6.41 |
| CHEMBL77288 | — | — | 1 | 6.35 |
| CHEMBL77062 | — | — | 1 | 6.30 |
| CHEMBL76877 | — | — | 1 | 6.25 |
| CHEMBL80216 | — | — | 1 | 6.21 |
| CHEMBL305941 | — | — | 1 | 6.20 |
| CHEMBL419831 | — | — | 1 | 6.18 |
| CHEMBL310822 | — | — | 1 | 6.10 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 6.10 |
| CHEMBL77789 | — | — | 1 | 6.04 |
| CHEMBL78215 | — | — | 1 | 6.00 |
| CHEMBL307729 | — | — | 1 | 5.92 |
| CHEMBL78222 | — | — | 1 | 5.90 |
| CHEMBL80388 | — | — | 1 | 5.85 |
| CHEMBL2112280 | — | — | 1 | 5.77 |
| CHEMBL309691 | — | — | 1 | 5.58 |
| CHEMBL307050 | — | — | 1 | 5.43 |
| CHEMBL74606 | — | — | 1 | 5.42 |
| CHEMBL78063 | — | — | 1 | 5.23 |
| CHEMBL2112281 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74661 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1170 | TESTOSTERONE PROPIONATE | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL310336 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL77751 | NRB 03731 | IC50 | = | 178.2 | nM | 6.75 |
| CHEMBL305896 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL75474 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2112282 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL78108 | — | IC50 | = | 377.3 | nM | 6.42 |
| CHEMBL78003 | — | IC50 | = | 386.9 | nM | 6.41 |
| CHEMBL77288 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL77062 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL76877 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL80216 | — | IC50 | = | 616.5 | nM | 6.21 |
| CHEMBL305941 | — | IC50 | = | 628.0 | nM | 6.20 |
| CHEMBL419831 | — | IC50 | = | 660.25 | nM | 6.18 |
| CHEMBL310822 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL77789 | — | IC50 | = | 915.0 | nM | 6.04 |
| CHEMBL78215 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL307729 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL78222 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL80388 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2112280 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL309691 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL307050 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL74606 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL78063 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2112281 | — | IC50 | = | 12050.0 | nM | 4.92 |