Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL3522 Target Snapshot

Steroid 17-alpha-hydroxylase/17,20 lyase · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
1,835Compounds
239Assays
11Approved Drugs
2,381.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Steroid 17-alpha-hydroxylase/17,20 lyase shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P05093. Start with neoplasm, then reuse UniProt P05093 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with neoplasm, then reuse UniProt P05093 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 3 linked drugs
Open source guide
Disease program
neoplasm

Steroid 17-alpha-hydroxylase/17,20 lyase shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ABIRATERONE, ORTERONEL, SEVITERONEL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Steroid 17-alpha-hydroxylase/17,20 lyase as ChEMBL target CHEMBL3522, mapped to UniProt P05093. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Steroid 17-alpha-hydroxylase/17,20 lyase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3522
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P05093
Steroid 17-alpha-hydroxylase/17,20 lyase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Steroid 17-alpha-hydroxylase/17,20 lyase is the right protein anchor across sources, using UniProt P05093 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSteroid 17-alpha-hydroxylase/17,20 lyase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP05093
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSteroid 17-alpha-hydroxylase/17,20 lyase
UniProt AccessionP05093
Component TypeProtein
Sequence Length508 aa

Steroid 17-alpha-hydroxylase/17,20 lyase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Steroid 17-alpha-hydroxylase/17,20 lyase, mapped to UniProt P05093. Sequence length is 508 aa.

Mapped IDP05093
Review nameSteroid 17-alpha-hydroxylase/17,20 lyase
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Steroid 17-alpha-hydroxylase/17,20 lyase shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
neoplasm
3 linked drugs · 3 direct · 3 efficacy
Linked drugABIRATERONE
Linked drugORTERONEL
Linked drugSEVITERONEL
Approved-linked Approved
prostate adenocarcinoma
3 linked drugs · 3 direct · 3 efficacy
Linked drugABIRATERONE
Linked drugABIRATERONE ACETATE
Linked drugORTERONEL
Approved-linked Approved
cancer
2 linked drugs · 2 direct · 2 efficacy
Linked drugABIRATERONE
Linked drugABIRATERONE ACETATE
Approved-linked Approved
metastatic prostate cancer
2 linked drugs · 2 direct · 2 efficacy
Linked drugABIRATERONE
Linked drugABIRATERONE ACETATE
Approved-linked Approved
prostate carcinoma
2 linked drugs · 2 direct · 2 efficacy
Linked drugABIRATERONE
Linked drugABIRATERONE ACETATE
Approved-linked Approved
adrenal gland disease
1 linked drug · 1 direct · 1 efficacy
Linked drugLEVOKETOCONAZOLE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ABIRATERONE, ORTERONEL, SEVITERONEL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseneoplasm
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

11
Approved
6
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC502,347.0
KI33.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4130227 10.77 IC50 0.017 Preclinical
CHEMBL3913908 9.14 IC50 0.73 Preclinical
CHEMBL3696099 9.0 IC50 1.0 Preclinical
CHEMBL4126996 9.0 IC50 1.0 Preclinical
CHEMBL4127656 9.0 IC50 1.0 Preclinical
CHEMBL4276910 9.0 IC50 1.0 Preclinical
CHEMBL2392006 8.92 Ki 1.2 Preclinical
CHEMBL74661 8.92 Ki 1.2 Preclinical
CHEMBL3666697 8.85 IC50 1.4 Preclinical
CHEMBL78108 8.85 Ki 1.4 Preclinical
Distribution

pChEMBL Value Distribution

36
5.0
91
5.5
174
6.0
187
6.5
209
7.0
159
7.5
163
8.0
42
8.5
6
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ABIRATERONE ACETATE
CHEMBL271227
Approved 2011
Properties Compare Identifier
POSACONAZOLE
CHEMBL1397
Approved 2005
Properties Compare Identifier
TIOCONAZOLE
CHEMBL1200438
Approved 1983
Properties Compare Identifier
ECONAZOLE
CHEMBL808
Approved 1982
Properties Compare Identifier
KETOCONAZOLE
CHEMBL157101
Approved 1981
Properties Compare Identifier
CLOTRIMAZOLE
CHEMBL104
Approved 1975
Properties Compare Identifier
TESTOSTERONE PROPIONATE
CHEMBL1170
Approved 1974
Properties Compare Identifier
MICONAZOLE
CHEMBL91
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

239
Total Assays
752
Tested Compounds
3
Assay Types
Binding — 198 assays, 752 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 119 266 6.6
single protein format 52 173 7.0
cell-based format 26 300 7.4
microsome format 1 13 6.9
ADME — 37 assays, 71 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 18 57 7.5
assay format 6 4 6.6
microsome format 5 4 7.0
cell-based format 4 3 6.7
tissue-based format 3 3 7.5
cell membrane format 1 0 —
Functional — 4 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 3 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine