Assay Detail
Functional
CHEMBL896729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at androgen receptor in mouse C2C12 cells by receptor transactivation assay
18
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | C2C12 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.84 | 9.36 |
| Intrinsic activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229264 | — | — | 1 | 9.36 |
| CHEMBL425646 | — | — | 1 | 8.64 |
| CHEMBL1170 | TESTOSTERONE PROPIONATE | 4.0 | 1 | 8.55 |
| CHEMBL393048 | — | — | 1 | 8.55 |
| CHEMBL233773 | — | — | 1 | 7.92 |
| CHEMBL391768 | — | — | 2 | 5.90 |
| CHEMBL233774 | — | — | 2 | 5.53 |
| CHEMBL391769 | — | — | 2 | 5.45 |
| CHEMBL234187 | — | — | 1 | 5.13 |
| CHEMBL234185 | — | — | 2 | 5.11 |
| CHEMBL391770 | — | — | 2 | 5.05 |
| CHEMBL234394 | — | — | 1 | - |
| CHEMBL233977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229264 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL425646 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1170 | TESTOSTERONE PROPIONATE | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL393048 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL233773 | — | EC50 | = | 11.9 | nM | 7.92 |
| CHEMBL391768 | — | EC50 | = | 1251.0 | nM | 5.90 |
| CHEMBL233774 | — | EC50 | = | 2959.0 | nM | 5.53 |
| CHEMBL391769 | — | EC50 | = | 3517.0 | nM | 5.45 |
| CHEMBL234187 | — | EC50 | = | 7459.0 | nM | 5.13 |
| CHEMBL234185 | — | EC50 | = | 7729.0 | nM | 5.11 |
| CHEMBL391770 | — | EC50 | = | 8962.0 | nM | 5.05 |
| CHEMBL234185 | — | Intrinsic activity | <= | 50.0 | % | - |
| CHEMBL391770 | — | Intrinsic activity | <= | 50.0 | % | - |
| CHEMBL391769 | — | Intrinsic activity | <= | 50.0 | % | - |
| CHEMBL391768 | — | Intrinsic activity | <= | 50.0 | % | - |
| CHEMBL233774 | — | Intrinsic activity | <= | 50.0 | % | - |
| CHEMBL233977 | — | EC50 | - | — | - | |
| CHEMBL234394 | — | EC50 | > | 3000.0 | nM | - |