Compound Detail
CHEMBL2040682
CICLESONIDE 💊 Approved Drug
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💊 Approved Drug
CC(C)C(=O)OCC(=O)[C@@]12O[C@H](C3CCCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C
Basic Information
| ChEMBL ID | CHEMBL2040682 |
| Name | CICLESONIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | LUKZNWIVRBCLON-GXOBDPJESA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL4594374 |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
20
Publications
11
Known Names
11
Indications
1
Mechanisms
Molecular Properties
540.7
MW (Da)
4.70
ALogP
7
HBA
1
HBD
99.1
PSA (Ų)
0.50
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2006 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Glucocorticoid receptor agonist | AGONIST | Glucocorticoid receptor | ✓ | ✓ |
Indications
Asthma Lung Diseases, Obstructive Nasal Obstruction Rhinitis, Allergic, Perennial Rhinitis, Allergic, Seasonal Rhinitis, Allergic, Seasonal Chronic Disease Hypersensitivity Respiratory Tract Diseases Severe Acute Respiratory Syndrome Pulmonary Disease, Chronic Obstructive
ATC Classification
R01AD13
ciclesonide
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
R03BA08
ciclesonide
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Activity Summary
IC50 3 meas. best 8.7
EC50 2 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 7.66 | 7.66 | 22.0 | 1 |
| SARS-CoV-2 CHEMBL4303835 | IC50 | 5.36 | 5.36 | 4330.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
| SARS-CoV-2 CHEMBL4303835 | EC50 | 4.69 | 4.69 | 20500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | IC50 | = | 2.0 | nM | 8.7 | Inhibition of glucocorticoid receptor (unknown origin) | 38516594 |
| Glucocorticoid receptor | EC50 | = | 22.0 | nM | 7.66 | Agonist activity at glucocorticoid receptor (unknown origin) expressed in K562 c... | 38516594 |
| SARS-CoV-2 | IC50 | = | 4330.0 | nM | 5.36 | Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in ... | - |
| Unchecked | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of porcine heart MDH using oxaloacetic acid as substrate preincubated... | 38864383 |
| SARS-CoV-2 | EC50 | = | 20500.0 | nM | 4.69 | Antiviral activity against SARS-CoV-2 | 38864383 |
Literature References
Data from ChEMBL 36 via Core Engine