Assay Detail
Functional
CHEMBL4303812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 5.37 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.72 |
| CHEMBL1208572 | SALINOMYCIN | 2.0 | 1 | 6.62 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.55 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 1 | 6.05 |
| CHEMBL600325 | PROSCILLARIDIN | 2.0 | 1 | 5.69 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 5.54 |
| CHEMBL176045 | FANCHININ | — | 1 | 5.52 |
| CHEMBL1410068 | — | — | 1 | 5.49 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 5.49 |
| CHEMBL46740 | BAZEDOXIFENE | 4.0 | 1 | 5.46 |
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 5.45 |
| CHEMBL2105450 | OXYCLOZANIDE | 2.0 | 1 | 5.43 |
| CHEMBL2107831 | LUSUTROMBOPAG | 4.0 | 1 | 5.42 |
| CHEMBL238188 | OSAJIN | — | 1 | 5.41 |
| CHEMBL184412 | DRONEDARONE | 4.0 | 1 | 5.41 |
| CHEMBL47298 | TILORONE | 2.0 | 1 | 5.39 |
| CHEMBL2040682 | CICLESONIDE | 4.0 | 1 | 5.36 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 5.36 |
| CHEMBL449782 | CEPHARANTHINE | 2.0 | 1 | 5.35 |
| CHEMBL4303716 | — | — | 1 | 5.35 |
| CHEMBL264241 | ANIDULAFUNGIN | 4.0 | 1 | 5.33 |
| CHEMBL47050 | PENFLURIDOL | 2.0 | 1 | 5.30 |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 5.29 |
| CHEMBL2355051 | CLOMIPHENE | 4.0 | 1 | 5.27 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.24 |
| CHEMBL1200848 | HYDROXYPROGESTERONE CAPROATE | 4.0 | 1 | 5.20 |
| CHEMBL75880 | PERHEXILINE | 4.0 | 1 | 5.20 |
| CHEMBL2010601 | IVACAFTOR | 4.0 | 1 | 5.18 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 5.18 |
| CHEMBL487 | DROLOXIFENE | 3.0 | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1751 | DIGOXIN | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1208572 | SALINOMYCIN | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL600325 | PROSCILLARIDIN | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL176045 | FANCHININ | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1410068 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL46740 | BAZEDOXIFENE | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL1655 | TOREMIFENE | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL2105450 | OXYCLOZANIDE | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL2107831 | LUSUTROMBOPAG | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL238188 | OSAJIN | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL184412 | DRONEDARONE | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL47298 | TILORONE | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL2040682 | CICLESONIDE | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL449782 | CEPHARANTHINE | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL4303716 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL264241 | ANIDULAFUNGIN | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL47050 | PENFLURIDOL | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL682 | AMODIAQUINE | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL2355051 | CLOMIPHENE | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL75880 | PERHEXILINE | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL1200848 | HYDROXYPROGESTERONE CAPROATE | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL2010601 | IVACAFTOR | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL487 | DROLOXIFENE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL305660 | EBASTINE | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL187709 | TRIPARANOL | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL73451 | MEQUITAZINE | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL504323 | BERBAMINE | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL461101 | ELTROMBOPAG | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL841 | LOPERAMIDE | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL4065616 | REMDESIVIR | IC50 | = | 11410.0 | nM | 4.94 |
| CHEMBL1526240 | DIHYDROGAMBOGIC ACID | IC50 | = | 13370.0 | nM | 4.87 |
| CHEMBL1242 | PHENAZOPYRIDINE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1889436 | OUABAIN OCTAHYDRATE | IC50 | < | 97.0 | nM | - |
| CHEMBL254219 | DIGITOXIN | IC50 | < | 230.0 | nM | - |
| CHEMBL7568 | QUINACRINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL590799 | CAMOSTAT | IC50 | > | 50000.0 | nM | - |
| CHEMBL506569 | LANATOSIDE C | IC50 | > | 50000.0 | nM | - |