Compound Detail
CHEMBL7568
QUINACRINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL7568 |
| Name | QUINACRINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | GPKJTRJOBQGKQK-UHFFFAOYSA-N |
58
Targets
145
Activities
4
Assay Types
8
PK Parameters
20
Publications
5
Known Names
6
Indications
Molecular Properties
400.0
MW (Da)
5.97
ALogP
4
HBA
1
HBD
37.4
PSA (Ų)
0.45
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Withdrawn |
| Chirality | Racemic |
Indications
Amebiasis Carcinoma, Renal Cell Creutzfeldt-Jakob Syndrome Prostatic Neoplasms, Castration-Resistant Carcinoma, Non-Small-Cell Lung Colorectal Neoplasms
ATC Classification
P01AX05
mepacrine
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
Drug Warnings
Withdrawn
General Warning
questions about the safety of the drug
Activity Summary
IC50 83 meas. best 7.89
EC50 38 meas. best 8.3
Ki 22 meas. best 6.58
Kd 2 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | EC50 | 8.3 | 7.8733 | 5.0 | 9 |
| Plasmodium falciparum CHEMBL364 | IC50 | 7.89 | 7.1863 | 13.0 | 8 |
| Major prion protein CHEMBL3698 | IC50 | 7.02 | 7.02 | 95.1 | 1 |
| UV4 CHEMBL612800 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| Plasmodium yoelii CHEMBL612889 | IC50 | 6.78 | 6.78 | 165.7 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 6.64 | 6.1123 | 230.0 | 13 |
| U2OS CHEMBL615023 | EC50 | 6.6 | 6.6 | 250.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 6.58 | 6.58 | 266.0 | 1 |
| Riboflavin-binding protein CHEMBL1944489 | Kd | 6.58 | 6.58 | 264.0 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 6.56 | 6.56 | 277.0 | 1 |
| ScN2a CHEMBL613872 | EC50 | 6.52 | 6.3067 | 300.0 | 3 |
| Major prion protein CHEMBL4869 | EC50 | 6.52 | 6.52 | 300.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 6.46 | 6.46 | 343.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 6.45 | 6.45 | 359.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 6.35 | 6.35 | 448.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 6.25 | 6.25 | 560.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 6.14 | 6.02 | 719.0 | 4 |
| Unchecked CHEMBL612545 | IC50 | 6.13 | 5.3486 | 739.0 | 7 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.12 | 6.12 | 761.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 6.08 | 6.08 | 833.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 6.07 | 6.07 | 855.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | IC50 | 6.02 | 6.02 | 964.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | Ki | 5.99 | 5.99 | 1015.0 | 1 |
| Ebolavirus CHEMBL4434621 | IC50 | 5.98 | 5.98 | 1050.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 5.9 | 5.9 | 1255.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | IC50 | 5.88 | 5.88 | 1318.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | IC50 | 5.83 | 5.83 | 1489.0 | 1 |
| CHO-AA8 CHEMBL614555 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | IC50 | 5.74 | 5.74 | 1825.0 | 1 |
| Alpha-1B adrenergic receptor CHEMBL315 | Ki | 5.72 | 5.72 | 1890.0 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | IC50 | 5.7 | 5.7 | 1983.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | IC50 | 5.68 | 5.68 | 2065.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | IC50 | 5.64 | 5.64 | 2280.0 | 1 |
| Zika virus CHEMBL4296612 | EC50 | 5.64 | 5.64 | 2270.0 | 1 |
| U2OS CHEMBL615023 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | IC50 | 5.58 | 5.58 | 2663.0 | 1 |
| Acetylcholinesterase CHEMBL220 | IC50 | 5.57 | 5.57 | 2667.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | Ki | 5.57 | 5.57 | 2684.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 5.54 | 5.54 | 2872.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 5.54 | 5.54 | 2896.0 | 1 |
| MDA-MB-231 CHEMBL400 | IC50 | 5.49 | 5.49 | 3250.0 | 2 |
| Aldehyde oxidase CHEMBL3257 | IC50 | 5.48 | 5.48 | 3300.0 | 1 |
| Sodium channel alpha subunits; brain (Types I, II, III) CHEMBL2096682 | IC50 | 5.48 | 5.48 | 3300.0 | 1 |
| Alpha-1B adrenergic receptor CHEMBL315 | IC50 | 5.47 | 5.47 | 3414.0 | 1 |
| Histamine H2 receptor CHEMBL1941 | Ki | 5.46 | 5.46 | 3476.0 | 1 |
| Histamine H2 receptor CHEMBL1941 | IC50 | 5.45 | 5.45 | 3535.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | IC50 | 5.43 | 5.43 | 3736.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | IC50 | 5.41 | 5.41 | 3857.0 | 1 |
| MDA-MB-468 CHEMBL614335 | IC50 | 5.4 | 5.4 | 3960.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 5.1 | mL.min-1.kg-1 | Homo sapiens |
| Fu | 0.103 | - | - |
| Fu | 0.0002 | - | - |
| Fu | 0.103 | - | Homo sapiens |
| Fu | 0.13 | - | Homo sapiens |
| Ka | 7.0 | 10^3/M | Homo sapiens |
| MRT | 150.0 | hr | Homo sapiens |
| T1/2 | 120.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine