Assay Detail
Binding
CHEMBL5149192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | ScN2a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.52 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 7.02 |
| CHEMBL5081846 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7568 | QUINACRINE | IC50 | = | 95.1 | nM | 7.02 |
| CHEMBL5081846 | — | IC50 | = | 949.9 | nM | 6.02 |