Major prion protein · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P04925. Use UniProt P04925 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04925 as the stable identity anchor, then attach disease evidence before program review.
Major prion protein
Review this target as Major prion protein, mapped to UniProt P04925. Sequence length is 254 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Major prion protein as ChEMBL target CHEMBL3698, mapped to UniProt P04925. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Major prion protein is the right protein anchor across sources, using UniProt P04925 as the stable mapping.
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| Preferred Name | Major prion protein |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P04925 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Major prion protein |
| UniProt Accession | P04925 |
| Component Type | Protein |
| Sequence Length | 254 aa |
Major prion protein
Review this target as Major prion protein, mapped to UniProt P04925. Sequence length is 254 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL7568 | 7.02 | IC50 | 95.1 | Approved |
| CHEMBL5081846 | 6.02 | IC50 | 949.9 | Preclinical |
| CHEMBL71 | 5.7 | EC50 | 2000.0 | Approved |
| CHEMBL1631114 | 4.7 | Kd | 20000.0 | Preclinical |
| CHEMBL1631205 | 4.66 | Kd | 21900.0 | Preclinical |
| CHEMBL1631121 | 4.31 | Kd | 48600.0 | Preclinical |
| CHEMBL1631113 | 4.29 | Kd | 51200.0 | Preclinical |
| CHEMBL1631116 | 4.29 | Kd | 50800.0 | Preclinical |
| CHEMBL1631115 | 4.07 | Kd | 86100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 2 | 6.5 |
| single protein format | 7 | 6 | 4.4 |
| assay format | 2 | 1 | 5.7 |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |