Major prion protein · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P04156. Use UniProt P04156 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04156 as the stable identity anchor, then attach disease evidence before program review.
Major prion protein
Review this target as Major prion protein, mapped to UniProt P04156. Sequence length is 253 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Major prion protein as ChEMBL target CHEMBL4869, mapped to UniProt P04156. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Major prion protein is the right protein anchor across sources, using UniProt P04156 as the stable mapping.
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| Preferred Name | Major prion protein |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P04156 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Major prion protein |
| UniProt Accession | P04156 |
| Component Type | Protein |
| Sequence Length | 253 aa |
Major prion protein
Review this target as Major prion protein, mapped to UniProt P04156. Sequence length is 253 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6061566 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5779401 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL5907420 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL1499411 | 6.85 | IC50 | 141.33 | Preclinical |
| CHEMBL1489869 | 6.85 | IC50 | 142.56 | Preclinical |
| CHEMBL5901795 | 6.66 | IC50 | 220.0 | Preclinical |
| CHEMBL7568 | 6.52 | EC50 | 300.0 | Approved |
| CHEMBL1538068 | 6.49 | IC50 | 320.71 | Preclinical |
| CHEMBL1368980 | 6.38 | IC50 | 412.1 | Preclinical |
| CHEMBL1587670 | 6.12 | IC50 | 759.13 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 0 | — |
| assay format | 1 | 4 | 7.3 |
| cell-based format | 1 | 7 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 240 | 5.4 |