Assay Detail
Functional
CHEMBL812709
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In vitro cytotoxicity against transformed chinese hamster fibroblast line UV4.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | UV4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.58 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17138 | — | — | 1 | 8.30 |
| CHEMBL264736 | — | — | 1 | 7.82 |
| CHEMBL275431 | — | — | 1 | 7.43 |
| CHEMBL18038 | — | — | 1 | 7.10 |
| CHEMBL17751 | — | — | 1 | 7.00 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 6.85 |
| CHEMBL273595 | — | — | 1 | 6.80 |
| CHEMBL278918 | — | — | 1 | 6.77 |
| CHEMBL17360 | — | — | 1 | 6.47 |
| CHEMBL17623 | — | — | 1 | 6.23 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 6.22 |
| CHEMBL17987 | — | — | 1 | 6.17 |
| CHEMBL17942 | — | — | 1 | 5.92 |
| CHEMBL18135 | — | — | 1 | 5.26 |
| CHEMBL274253 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17138 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL264736 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL275431 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL18038 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL17751 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL273595 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL278918 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL17360 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL17623 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL17987 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL17942 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL18135 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL274253 | — | IC50 | = | 42000.0 | nM | 4.38 |