Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL938340

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC.
Antimicrob Agents Chemother (2007) 51 : 2164 -2172
PubMed 17371810 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 6.73 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7568 QUINACRINE 4.0 1 7.48
CHEMBL404610 1 7.47
CHEMBL264408 1 7.16
CHEMBL258675 1 7.13
CHEMBL92547 1 6.95
CHEMBL329647 1 6.94
CHEMBL328742 1 6.91
CHEMBL260934 1 6.89
CHEMBL263380 1 6.87
CHEMBL56640 1 6.87
CHEMBL264145 1 6.83
CHEMBL264512 1 6.75
CHEMBL76 CHLOROQUINE 4.0 1 6.53
CHEMBL258727 1 6.52
CHEMBL258944 1 6.50
CHEMBL405356 1 6.47
CHEMBL258645 1 6.20
CHEMBL90969 1 6.10
CHEMBL259289 1 6.08
CHEMBL227559 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7568 QUINACRINE EC50 = 33.0 nM 7.48
CHEMBL404610 EC50 = 34.0 nM 7.47
CHEMBL264408 EC50 = 69.0 nM 7.16
CHEMBL258675 EC50 = 74.0 nM 7.13
CHEMBL92547 EC50 = 112.0 nM 6.95
CHEMBL329647 EC50 = 116.0 nM 6.94
CHEMBL328742 EC50 = 124.0 nM 6.91
CHEMBL260934 EC50 = 129.0 nM 6.89
CHEMBL263380 EC50 = 136.0 nM 6.87
CHEMBL56640 EC50 = 135.0 nM 6.87
CHEMBL264145 EC50 = 147.0 nM 6.83
CHEMBL264512 EC50 = 180.0 nM 6.75
CHEMBL76 CHLOROQUINE EC50 = 293.0 nM 6.53
CHEMBL258727 EC50 = 303.0 nM 6.52
CHEMBL258944 EC50 = 319.0 nM 6.50
CHEMBL405356 EC50 = 341.0 nM 6.47
CHEMBL258645 EC50 = 629.0 nM 6.20
CHEMBL90969 EC50 = 791.0 nM 6.10
CHEMBL259289 EC50 = 823.0 nM 6.08
CHEMBL227559 EC50 = 1085.0 nM 5.96