Assay Detail
Functional
CHEMBL3055249
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pharmacophore-based predictive model generation for potent antimalarials targeting haem detoxification pathway
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.08 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1107 | HALOFANTRINE | 4.0 | 1 | 8.55 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 8.04 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | — | 1 | 8.04 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 8.03 |
| CHEMBL1213257 | AMOPYROQUINE | 2.0 | 1 | 7.92 |
| CHEMBL343770 | TEBAQUINE | — | 1 | 7.89 |
| CHEMBL1630 | — | — | 1 | 7.75 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 7.41 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 7.37 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 7.29 |
| CHEMBL588619 | CINCHONINE | -1.0 | 1 | 7.25 |
| CHEMBL510457 | DEHYDROXY TEBAQUINE | — | 1 | 7.16 |
| CHEMBL2263229 | DEHYDROXYFLUORO TEBAQUINE | — | 1 | 7.16 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.09 |
| CHEMBL448594 | Chloroquine-pyrolidinyl | — | 1 | 7.05 |
| CHEMBL533841 | CINCHONIDINE | -1.0 | 1 | 7.04 |
| CHEMBL1631 | BIDESETHYL AMODIAQUINE | — | 1 | 6.77 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.72 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 6.14 |
| CHEMBL1656 | BIDESETHYL CHLOROQUINE | — | 1 | 5.89 |
| CHEMBL468610 | — | — | 1 | 5.89 |
| CHEMBL375673 | — | — | 1 | 5.64 |
| CHEMBL217786 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1107 | HALOFANTRINE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL316098 | N-TERT-BUTYL-AMODIAQUINE | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1213257 | AMOPYROQUINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL343770 | TEBAQUINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1630 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL588619 | CINCHONINE | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL510457 | DEHYDROXY TEBAQUINE | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2263229 | DEHYDROXYFLUORO TEBAQUINE | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL170 | QUININE | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL448594 | Chloroquine-pyrolidinyl | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL533841 | CINCHONIDINE | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1631 | BIDESETHYL AMODIAQUINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1656 | BIDESETHYL CHLOROQUINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL468610 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL375673 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL217786 | — | IC50 | = | 15000.0 | nM | 4.82 |