Compound Detail
CHEMBL1294
QUINIDINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1294 |
| Name | QUINIDINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | LOUPRKONTZGTKE-LHHVKLHASA-N |
| Therapeutic | ✓ Yes |
36
Targets
166
Activities
4
Assay Types
30
PK Parameters
20
Publications
6
Known Names
15
Indications
Molecular Properties
324.4
MW (Da)
3.17
ALogP
4
HBA
1
HBD
45.6
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1950 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Arrhythmias, Cardiac Amyotrophic Lateral Sclerosis Atrial Fibrillation Death, Sudden, Cardiac Multiple Sclerosis Myocardial Infarction Ventricular Fibrillation Depressive Disorder Depressive Disorder, Major Migraine Disorders Constipation Hepatitis B, Chronic Non-alcoholic Fatty Liver Disease Respiratory Syncytial Virus Infections Severe Acute Respiratory Syndrome
ATC Classification
C01BA01
quinidine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
C01BA51
quinidine, combinations excl. psycholeptics
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
C01BA71
quinidine, combinations with psycholeptics
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
Activity Summary
IC50 136 meas. best 8.7
Ki 18 meas. best 8.01
EC50 11 meas. best 8.02
Kd 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 8.7 | 7.3052 | 2.0 | 69 |
| Plasmodium falciparum CHEMBL364 | IC50 | 8.4 | 7.0656 | 4.0 | 9 |
| Plasmodium falciparum CHEMBL364 | EC50 | 8.02 | 7.735 | 9.6 | 2 |
| Cytochrome P450 2D6 CHEMBL289 | Ki | 8.01 | 7.4367 | 9.8 | 6 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 6.52 | 6.2429 | 300.0 | 7 |
| ATP-dependent translocase ABCB1 CHEMBL4302 | Ki | 6.37 | 5.628 | 430.0 | 5 |
| Cavia porcellus CHEMBL369 | Kd | 6.0 | 6.0 | 1000.0 | 1 |
| ATP-dependent translocase ABCB1 CHEMBL4302 | IC50 | 6.0 | 5.1863 | 1000.0 | 8 |
| Cholinesterase CHEMBL1914 | IC50 | 5.91 | 5.91 | 1230.0 | 1 |
| A-type voltage-gated potassium channel KCND2 CHEMBL1075227 | IC50 | 5.66 | 5.66 | 2200.0 | 1 |
| Cytochrome P450 2D26 CHEMBL2483 | IC50 | 5.55 | 5.55 | 2800.0 | 1 |
| Sodium channel alpha subunits; brain (Types I, II, III) CHEMBL2096682 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.47 | 5.3129 | 3380.0 | 7 |
| ScN2a CHEMBL613872 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C CHEMBL3762 | IC50 | 5.25 | 5.125 | 5600.0 | 2 |
| Solute carrier family 22 member 1 CHEMBL2073670 | Ki | 5.22 | 5.03 | 6000.0 | 2 |
| Voltage-gated L-type calcium channel CHEMBL2095229 | IC50 | 5.19 | 5.19 | 6400.0 | 1 |
| Sodium channel protein type 5 subunit alpha CHEMBL1980 | IC50 | 5.16 | 4.97 | 6900.0 | 2 |
| Potassium voltage-gated channel subfamily A member 5 CHEMBL4306 | IC50 | 5.14 | 5.14 | 7300.0 | 1 |
| Cholinesterase CHEMBL5763 | IC50 | 5.13 | 5.13 | 7370.0 | 1 |
| Solute carrier organic anion transporter family member 1A1 CHEMBL1781859 | Ki | 5.03 | 5.03 | 9270.0 | 1 |
| ATP-dependent translocase ABCB1 CHEMBL3467 | IC50 | 5.0 | 5.0 | 10000.0 | 2 |
| Unchecked CHEMBL612545 | EC50 | 4.99 | 4.99 | 10260.0 | 1 |
| Multidrug and toxin extrusion protein 1 CHEMBL1743126 | IC50 | 4.95 | 4.95 | 11200.0 | 1 |
| Solute carrier family 22 member 1 CHEMBL2073670 | IC50 | 4.9 | 4.9 | 12700.0 | 1 |
| ATP-dependent translocase ABCB1 CHEMBL2573 | IC50 | 4.89 | 4.89 | 13000.0 | 2 |
| Solute carrier family 22 member 2 CHEMBL1770032 | IC50 | 4.84 | 4.84 | 14600.0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C CHEMBL2366456 | IC50 | 4.81 | 4.81 | 15600.0 | 2 |
| Potassium channel subfamily T member 1 CHEMBL4739688 | IC50 | 4.8 | 4.45 | 15800.0 | 2 |
| Solute carrier family 22 member 1 CHEMBL5685 | Ki | 4.76 | 4.76 | 17500.0 | 1 |
| Solute carrier family 22 member 2 CHEMBL1770032 | Ki | 4.72 | 4.72 | 19100.0 | 1 |
| Cytochrome P450 2D1 CHEMBL2475 | IC50 | 4.7 | 4.7 | 19900.0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C CHEMBL1940 | IC50 | 4.7 | 4.7 | 19820.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.64 | 4.64 | 23000.0 | 1 |
| Solute carrier family 22 member 1 CHEMBL5685 | IC50 | 4.63 | 4.63 | 23400.0 | 1 |
| Heme CHEMBL4651321 | IC50 | 4.62 | 4.62 | 24000.0 | 1 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 4.58 | 4.58 | 25990.0 | 1 |
| Cytochrome P450 2D3 CHEMBL3057 | IC50 | 4.57 | 4.57 | 26900.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 4.55 | 4.55 | 28000.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | Ki | 4.5 | 4.5 | 32000.0 | 1 |
| ADMET CHEMBL612558 | IC50 | 4.46 | 4.46 | 34810.0 | 1 |
| ATP-binding cassette sub-family C member 4 CHEMBL1743128 | IC50 | 4.34 | 4.34 | 45800.0 | 1 |
| Cytochrome P450 2D4 CHEMBL4982 | IC50 | 4.33 | 4.33 | 47200.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 1880.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 1850.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 304.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 302.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 5310.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 4920.0 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 5.33 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 3.4 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.5 | mL.min-1.kg-1 | Homo sapiens |
| CL | 5.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 13.0 | mL.min-1.kg-1 | Macaca |
| CL | 34.0 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 6.17 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 72.44 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| CL | 33.3 | mL.min-1.kg-1 | Homo sapiens |
| CL | 13.5 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 20.3 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 4.02 | mL.min-1.kg-1 | Homo sapiens |
| F | 79.0 | % | Homo sapiens |
| F | 75.0 | % | Homo sapiens |
| Fu | 0.13 | - | - |
| Fu | 0.019 | - | - |
| Fu | 0.13 | - | Homo sapiens |
| Fu | 0.26 | - | Homo sapiens |
| Fu | 0.26 | - | Homo sapiens |
| Fu | 0.09 | - | Rattus norvegicus |
| Fu | 0.251 | - | Not specified |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine