Assay Detail
ADMET
CHEMBL3821691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.51 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 8.05 |
| CHEMBL211204 | — | — | 1 | 5.39 |
| CHEMBL3408523 | — | — | 1 | 5.15 |
| CHEMBL3818643 | — | — | 1 | 4.90 |
| CHEMBL3819606 | — | — | 1 | 4.78 |
| CHEMBL3819185 | — | — | 1 | 4.77 |
| CHEMBL3819226 | — | — | 1 | - |
| CHEMBL3818560 | — | — | 1 | - |
| CHEMBL3819349 | — | — | 1 | - |
| CHEMBL3408526 | — | — | 1 | - |
| CHEMBL3408529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL211204 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3408523 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3818643 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3819606 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL3819185 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL3819226 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3818560 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3819349 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3408526 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3408529 | — | IC50 | > | 20000.0 | nM | - |