Review anchor
Cytochrome P450 2D6
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Cytochrome P450 2D6
CHEMBL289
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2D6 as ChEMBL target CHEMBL289, mapped to UniProt P10635. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL289
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P10635
Cytochrome P450 2D6
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Cytochrome P450 2D6 matters
Cytochrome P450 2D6 is reviewed as Cytochrome P450 2D6 (UniProt P10635); the current evidence base includes 103 approved drugs, 27662 compounds, and 3314 assays, with lead potency reaching pChEMBL 10.3.
Protein context
Cytochrome P450 2D6
Cytochrome P450 2D6 Sequence length is 497 aa.
Review this target as Cytochrome P450 2D6, mapped to UniProt P10635. Sequence length is 497 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P10635
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 103 approved drugs, 27662 compounds, and 3314 assays for this target. The dominant activity type is IC50. CHEMBL180672 is the current potency anchor at pChEMBL 10.3.
Use CHEMBL180672 as the tractability anchor when discussing potency (pChEMBL 10.3).
Activity source · ChEMBL 36 via Core Engine
103 approved
pChEMBL 10.3
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Cytochrome P450 2D6 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P10635, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
27662
Total Compounds
3314
Total Assays
103
Approved Drugs
IC50: 8456.0, KI: 1013.0, EC50: 26.0, KD: 2.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL180672
|
10.3 | IC50 | — |
|
|
No preferred name
CHEMBL382741
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL220360
|
9.2 | IC50 | Clinical |
|
|
No preferred name
CHEMBL157101
|
8.7 | IC50 | Approved |
|
|
No preferred name
CHEMBL1091778
|
8.7 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
QUININE
CHEMBL170
|
2005 |
|
|
DULOXETINE
CHEMBL1175
|
2004 |
|
|
CINACALCET
CHEMBL1201284
|
2004 |
|
|
LEVOBUPIVACAINE
CHEMBL1201193
|
1999 |
|
|
CELECOXIB
CHEMBL118
|
1998 |
|
|
MIBEFRADIL
CHEMBL45816
|
1997 |
|
|
BUTENAFINE
CHEMBL990
|
1996 |
|
|
AZELASTINE
CHEMBL639
|
1996 |
|
|
CISAPRIDE
CHEMBL1729
|
1993 |
|
|
TACRINE
CHEMBL95
|
1993 |
|
|
PAROXETINE HYDROCHLORIDE
CHEMBL6067650
|
1992 |
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
TERBINAFINE
CHEMBL822
|
1992 |
|
|
PERGOLIDE
CHEMBL531
|
1988 |
|
|
OXICONAZOLE
CHEMBL1262
|
1988 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
OXYMETAZOLINE
CHEMBL762
|
1986 |
|
|
SULCONAZOLE
CHEMBL1221
|
1985 |
|
|
NALTREXONE
CHEMBL19019
|
1984 |
|
|
LABETALOL
CHEMBL429
|
1984 |
|
|
DEXTROMETHORPHAN
CHEMBL52440
|
1982 |
|
|
GENTIAN VIOLET
CHEMBL64894
|
1982 |
|
|
ECONAZOLE
CHEMBL808
|
1982 |
|
|
AMODIAQUINE
CHEMBL682
|
1982 |
|
|
KETOCONAZOLE
CHEMBL157101
|
1981 |
|
|
METOCLOPRAMIDE
CHEMBL86
|
1979 |
|
|
CLOTRIMAZOLE
CHEMBL104
|
1975 |
|
|
MICONAZOLE
CHEMBL91
|
1974 |
|
|
PERHEXILINE
CHEMBL75880
|
1974 |
|
|
PYRILAMINE
CHEMBL511
|
1973 |
|
|
BUPIVACAINE HYDROCHLORIDE
CHEMBL1200396
|
1972 |
|
|
DIPHENIDOL
CHEMBL936
|
1967 |
|
|
DOXAPRAM
CHEMBL1754
|
1965 |
|
|
NORTRIPTYLINE
CHEMBL445
|
1964 |
|
|
QUINIDINE SULFATE
CHEMBL3707183
|
1962 |
|
|
PHENELZINE
CHEMBL1089
|
1961 |
|
|
ORPHENADRINE
CHEMBL900
|
1957 |
|
|
PERPHENAZINE
CHEMBL567
|
1957 |
|
|
PROCHLORPERAZINE
CHEMBL728
|
1956 |
|
|
PROMAZINE
CHEMBL564
|
1956 |
|
|
QUINIDINE
CHEMBL1294
|
1950 |
|
|
METHYLERGONOVINE
CHEMBL1201356
|
1946 |
|
|
PIPAMAZINE
CHEMBL1909072
|
— |
Source Header