Compound Detail
CHEMBL6067650
PAROXETINE HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
Cl.Cl.Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1.Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1.O
10
Targets
18
Activities
2
Assay Types
0
PK Parameters
20
Publications
11
Known Names
9
Indications
2
Mechanisms
Molecular Properties
329.4
MW (Da)
3.33
ALogP
4
HBA
1
HBD
39.7
PSA (Ų)
0.93
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1992 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serotonin transporter inhibitor | INHIBITOR | Sodium-dependent serotonin transporter | ✓ | ✓ |
| Serotonin transporter inhibitor | INHIBITOR | Sodium-dependent serotonin transporter | ✓ | ✓ |
Indications
Anxiety Disorders Depressive Disorder, Major Obsessive-Compulsive Disorder Panic Disorder Phobia, Social Stress Disorders, Post-Traumatic Premature Ejaculation Anxiety Depressive Disorder
Activity Summary
IC50 14 meas. best 6.02
Ki 4 meas. best 10.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter CHEMBL313 | Ki | 10.3 | 10.3 | 0.1 | 1 |
| Transporter CHEMBL6184 | Ki | 7.23 | 7.23 | 59.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | Ki | 7.01 | 7.01 | 98.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 6.02 | 6.02 | 960.0 | 1 |
| Beta-adrenergic receptor kinase 1 CHEMBL3711550 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.7 | 5.7 | 2000.0 | 1 |
| Beta-adrenergic receptor kinase 1 CHEMBL4079 | IC50 | 5.6 | 5.15 | 2500.0 | 2 |
| Cytochrome P450 1A2 CHEMBL3356 | IC50 | 5.27 | 5.27 | 5330.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 4.62 | 4.62 | 24100.0 | 1 |
| Bile salt export pump CHEMBL6020 | IC50 | 4.16 | 4.16 | 68910.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine