Assay Detail
Binding
CHEMBL3854619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GRK2 S670A mutant assessed as decrease in phosphorylation of tubulin preincubated for 30 mins followed by ATP addition
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.60 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067650 | PAROXETINE HYDROCHLORIDE | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067650 | PAROXETINE HYDROCHLORIDE | IC50 | = | 2500.0 | nM | 5.60 |