Assay Detail
Binding
CHEMBL1291960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from serotonin transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation counting
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.18 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067650 | PAROXETINE HYDROCHLORIDE | 4.0 | 1 | 10.30 |
| CHEMBL1289854 | — | — | 1 | 9.22 |
| CHEMBL1289190 | — | — | 1 | 9.00 |
| CHEMBL1289073 | — | — | 1 | 8.77 |
| CHEMBL1289748 | — | — | 1 | 8.70 |
| CHEMBL1290067 | — | — | 1 | 8.70 |
| CHEMBL1201082 | FLUOXETINE HYDROCHLORIDE | 4.0 | 1 | 8.70 |
| CHEMBL1288490 | — | — | 1 | 8.60 |
| CHEMBL1289973 | — | — | 1 | 8.54 |
| CHEMBL1290741 | — | — | 1 | 8.48 |
| CHEMBL1289072 | — | — | 1 | 8.41 |
| CHEMBL1289191 | — | — | 1 | 8.37 |
| CHEMBL1289972 | — | — | 1 | 8.23 |
| CHEMBL1289855 | — | — | 1 | 8.23 |
| CHEMBL1289642 | — | — | 1 | 8.19 |
| CHEMBL1289302 | — | — | 1 | 8.15 |
| CHEMBL536952 | — | — | 1 | 8.14 |
| CHEMBL1289533 | — | — | 1 | 8.04 |
| CHEMBL1290174 | — | — | 1 | 8.00 |
| CHEMBL1289534 | — | — | 1 | 7.99 |
| CHEMBL1289420 | — | — | 1 | 7.96 |
| CHEMBL1289303 | — | — | 1 | 7.88 |
| CHEMBL1290742 | — | — | 1 | 7.85 |
| CHEMBL541124 | — | — | 1 | 7.73 |
| CHEMBL536264 | — | — | 1 | 7.68 |
| CHEMBL1290622 | — | — | 1 | 7.67 |
| CHEMBL1290068 | — | — | 1 | 7.58 |
| CHEMBL1289643 | — | — | 1 | 7.52 |
| CHEMBL1289747 | — | — | 1 | 7.33 |
| CHEMBL1289421 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067650 | PAROXETINE HYDROCHLORIDE | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL1289854 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1289190 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1289073 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1289748 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1290067 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1201082 | FLUOXETINE HYDROCHLORIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1288490 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1289973 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1290741 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL1289072 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1289191 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL1289972 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL1289855 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL1289642 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL1289302 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL536952 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL1289533 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1290174 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL1289534 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL1289420 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL1289303 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL1290742 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL541124 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL536264 | — | Ki | = | 21.1 | nM | 7.68 |
| CHEMBL1290622 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL1290068 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL1289643 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL1289747 | — | Ki | = | 46.7 | nM | 7.33 |
| CHEMBL1289421 | — | Ki | = | 49.5 | nM | 7.30 |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | Ki | = | 413.0 | nM | 6.38 |