Sodium-dependent serotonin transporter · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P31652. Use UniProt P31652 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31652 as the stable identity anchor, then attach disease evidence before program review.
Sodium-dependent serotonin transporter
Review this target as Sodium-dependent serotonin transporter, mapped to UniProt P31652. Sequence length is 630 aa.
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This review treats Sodium-dependent serotonin transporter as ChEMBL target CHEMBL313, mapped to UniProt P31652. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sodium-dependent serotonin transporter |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P31652 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium-dependent serotonin transporter |
| UniProt Accession | P31652 |
| Component Type | Protein |
| Sequence Length | 630 aa |
Sodium-dependent serotonin transporter
Review this target as Sodium-dependent serotonin transporter, mapped to UniProt P31652. Sequence length is 630 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL106481 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL23034 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL435287 | 10.77 | Ki | 0.017 | Preclinical |
| CHEMBL421027 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL423269 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL553648 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL300069 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL142158 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL6067650 | 10.3 | Ki | 0.05 | Approved |
| CHEMBL121952 | 10.29 | Kd | 0.051 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 114 | 1,124 | 6.8 |
| single protein format | 111 | 1,027 | 7.0 |
| assay format | 70 | 554 | 7.1 |
| subcellular format | 63 | 712 | 7.1 |
| cell membrane format | 53 | 484 | 7.2 |
| cell-based format | 16 | 66 | 6.5 |
| organism-based format | 2 | 35 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 29 | 34 | 6.3 |
| tissue-based format | 20 | 90 | 5.9 |
| assay format | 18 | 195 | 6.8 |
| subcellular format | 6 | 112 | 7.0 |