Review anchor
Sodium-dependent serotonin transporter
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Sodium-dependent serotonin transporter
CHEMBL313
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium-dependent serotonin transporter as ChEMBL target CHEMBL313, mapped to UniProt P31652. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL313
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P31652
Sodium-dependent serotonin transporter
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Sodium-dependent serotonin transporter matters
Sodium-dependent serotonin transporter is reviewed as Sodium-dependent serotonin transporter (UniProt P31652); the current evidence base includes 57 approved drugs, 4751 compounds, and 501 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Sodium-dependent serotonin transporter
Sodium-dependent serotonin transporter Sequence length is 630 aa.
Review this target as Sodium-dependent serotonin transporter, mapped to UniProt P31652. Sequence length is 630 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P31652
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 57 approved drugs, 4751 compounds, and 501 assays for this target. The dominant activity type is KI. CHEMBL106481 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL106481 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
57 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Sodium-dependent serotonin transporter matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P31652, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
4751
Total Compounds
501
Total Assays
57
Approved Drugs
IC50: 1710.0, KI: 3644.0, EC50: 70.0, KD: 5.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL106481
|
11.0 | Ki | — |
|
|
No preferred name
CHEMBL23034
|
10.9 | Ki | — |
|
|
No preferred name
CHEMBL435287
|
10.8 | Ki | — |
|
|
No preferred name
CHEMBL423269
|
10.5 | Ki | — |
|
|
No preferred name
CHEMBL421027
|
10.5 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
COCAINE HYDROCHLORIDE
CHEMBL529437
|
2017 |
|
|
COCAINE
CHEMBL370805
|
2017 |
|
|
LEVOMILNACIPRAN
CHEMBL99946
|
2013 |
|
|
VORTIOXETINE
CHEMBL2104993
|
2013 |
|
|
VILAZODONE
CHEMBL439849
|
2011 |
|
|
MILNACIPRAN
CHEMBL259209
|
2009 |
|
|
DESVENLAFAXINE
CHEMBL1118
|
2008 |
|
|
DULOXETINE
CHEMBL1175
|
2004 |
|
|
ATOMOXETINE
CHEMBL641
|
2002 |
|
|
ESCITALOPRAM
CHEMBL1508
|
2002 |
|
|
CITALOPRAM
CHEMBL549
|
1998 |
|
|
REBOXETINE
CHEMBL14370
|
1997 |
|
|
NEFAZODONE
CHEMBL623
|
1994 |
|
|
FLUVOXAMINE
CHEMBL814
|
1994 |
|
|
VENLAFAXINE
CHEMBL637
|
1993 |
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
PAROXETINE HYDROCHLORIDE
CHEMBL6067650
|
1992 |
|
|
SERTRALINE HYDROCHLORIDE
CHEMBL1709
|
1991 |
|
|
SERTRALINE
CHEMBL809
|
1991 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
FLUOXETINE HYDROCHLORIDE
CHEMBL1201082
|
1987 |
|
|
NOMIFENSINE
CHEMBL273575
|
1984 |
|
|
MAZINDOL
CHEMBL781
|
1973 |
|
|
VANCOMYCIN
CHEMBL262777
|
1964 |
|
|
DESIPRAMINE HYDROCHLORIDE
CHEMBL1696
|
1964 |
|
|
DESIPRAMINE
CHEMBL72
|
1964 |
|
|
FENFLURAMINE
CHEMBL87493
|
1963 |
|
|
IMIPRAMINE
CHEMBL11
|
1959 |
|
|
IMIPRAMINE HYDROCHLORIDE
CHEMBL1692
|
1959 |
|
|
BROMPHENIRAMINE
CHEMBL811
|
1957 |
|
|
MEPERIDINE
CHEMBL607
|
1942 |
|
|
MEPERIDINE HYDROCHLORIDE
CHEMBL1701
|
1942 |
|
|
INDALPINE
CHEMBL276520
|
— |
Source Header