Compound Detail
CHEMBL1709
SERTRALINE HYDROCHLORIDE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
5
Targets
22
Activities
2
Assay Types
0
PK Parameters
20
Publications
11
Known Names
9
Indications
1
Mechanisms
Molecular Properties
306.2
MW (Da)
5.18
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.81
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1991 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serotonin transporter inhibitor | INHIBITOR | Sodium-dependent serotonin transporter | ✓ | ✓ |
Indications
Depressive Disorder, Major Headache Obsessive-Compulsive Disorder Phobia, Social Stress Disorders, Post-Traumatic Depressive Disorder Intellectual Disability Panic Disorder Huntington Disease
Drug Warnings
Black Box Warning
psychiatric toxicity
Activity Summary
IC50 21 meas. best 7.16
EC50 1 meas. best 5.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter CHEMBL313 | IC50 | 7.16 | 7.16 | 70.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 6.28 | 6.28 | 520.0 | 1 |
| Norepinephrine transporter CHEMBL304 | IC50 | 6.14 | 6.14 | 720.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.4 | 5.0857 | 3981.1 | 7 |
| Unchecked CHEMBL612545 | IC50 | 5.33 | 4.8355 | 4711.3 | 11 |
| Unchecked CHEMBL612545 | EC50 | 5.09 | 5.09 | 8180.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19734910 | 10.1038/nchembio.215 | Plasmodium falciparum | 7 |
| 16464584 | 10.1016/j.bmcl.2006.01.078 | Trichomonas vaginalis | 2 |
| 16464584 | 10.1016/j.bmcl.2006.01.078 | Spermatozoa | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/EOS300108 | HepG2 | 1 |
| 6492080 | 10.1021/jm00377a021 | Sodium-dependent dopamine transporter | 1 |
| 35253435 | 10.1021/acs.jmedchem.1c01845 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513141 | Staphylococcus aureus | 1 |
| - | 10.6019/CHEMBL4513141 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4513141 | Escherichia coli | 1 |
| - | 10.6019/CHEMBL4513141 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513141 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 6492080 | 10.1021/jm00377a021 | Norepinephrine transporter | 1 |
| 6492080 | 10.1021/jm00377a021 | Sodium-dependent serotonin transporter | 1 |
Data from ChEMBL 36 via Core Engine