Assay Detail
Functional
CHEMBL782596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HT
65
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 6.15 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284994 | — | — | 2 | 7.41 |
| CHEMBL1743845 | — | — | 1 | 7.40 |
| CHEMBL1788361 | — | — | 1 | 7.30 |
| CHEMBL809 | SERTRALINE | 4.0 | 2 | 7.22 |
| CHEMBL1709 | SERTRALINE HYDROCHLORIDE | 4.0 | 1 | 7.16 |
| CHEMBL39354 | — | — | 1 | 7.16 |
| CHEMBL37714 | — | — | 2 | 7.08 |
| CHEMBL1743855 | — | — | 1 | 7.05 |
| CHEMBL1788366 | — | — | 1 | 6.92 |
| CHEMBL1743860 | — | — | 1 | 6.92 |
| CHEMBL1743865 | — | — | 1 | 6.72 |
| CHEMBL39405 | — | — | 1 | 6.72 |
| CHEMBL38369 | — | — | 2 | 6.70 |
| CHEMBL1788364 | — | — | 1 | 6.66 |
| CHEMBL290359 | — | — | 1 | 6.66 |
| CHEMBL1743872 | — | — | 1 | 6.62 |
| CHEMBL1788367 | — | — | 1 | 6.60 |
| CHEMBL1788370 | — | — | 1 | 6.58 |
| CHEMBL1743854 | — | — | 1 | 6.47 |
| CHEMBL417704 | — | — | 1 | 6.46 |
| CHEMBL36050 | — | — | 2 | 6.43 |
| CHEMBL1743868 | — | — | 1 | 6.42 |
| CHEMBL1743851 | — | — | 1 | 6.42 |
| CHEMBL39591 | — | — | 1 | 6.41 |
| CHEMBL1743864 | — | — | 1 | 6.40 |
| CHEMBL1743849 | — | — | 1 | 6.37 |
| CHEMBL1743859 | — | — | 1 | 6.34 |
| CHEMBL38340 | — | — | 1 | 6.31 |
| CHEMBL1743874 | — | — | 1 | 6.30 |
| CHEMBL36714 | — | — | 2 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284994 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1743845 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1788361 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL809 | SERTRALINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1709 | SERTRALINE HYDROCHLORIDE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL39354 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL37714 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1743855 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1788366 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1743860 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1743865 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL39405 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL38369 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL290359 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1788364 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1743872 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1788367 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1788370 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1743854 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL417704 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL36050 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1743868 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1743851 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL39591 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1743864 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1743849 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL809 | SERTRALINE | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1743859 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL284994 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL38340 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1743874 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL36714 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL814 | FLUVOXAMINE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1743844 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL287499 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1743848 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1743852 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1788369 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL38120 | TAMETRALINE | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1743858 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL39856 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL36050 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1743861 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1788368 | TAMETRALINE HYDROCHLORIDE | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL1743873 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1743846 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL39856 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL36714 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL38369 | — | IC50 | = | 3100.0 | nM | 5.51 |