Compound Detail
CHEMBL38120
TAMETRALINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL38120 |
| Name | TAMETRALINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NVXPZMLRGBVYQV-WMLDXEAASA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
4
Known Names
Molecular Properties
237.3
MW (Da)
3.87
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 6 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Norepinephrine transporter CHEMBL304 | IC50 | 7.75 | 7.09 | 18.0 | 2 |
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 6.82 | 6.335 | 150.0 | 2 |
| Sodium-dependent serotonin transporter CHEMBL313 | IC50 | 6.08 | 5.465 | 840.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Norepinephrine transporter | IC50 | = | 18.0 | nM | 7.75 | Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothal... | 6492080 |
| Sodium-dependent dopamine transporter | IC50 | = | 150.0 | nM | 6.82 | Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum... | 6492080 |
| Norepinephrine transporter | IC50 | = | 370.0 | nM | 6.43 | Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothal... | 6492080 |
| Sodium-dependent serotonin transporter | IC50 | = | 840.0 | nM | 6.08 | Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, ... | 6492080 |
| Sodium-dependent dopamine transporter | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum... | 6492080 |
| Sodium-dependent serotonin transporter | IC50 | = | 14000.0 | nM | 4.85 | Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, ... | 6492080 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6492080 | 10.1021/jm00377a021 | Sodium-dependent dopamine transporter | 2 |
| 6492080 | 10.1021/jm00377a021 | Sodium-dependent serotonin transporter | 2 |
| 6492080 | 10.1021/jm00377a021 | Norepinephrine transporter | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
Data from ChEMBL 36 via Core Engine