Assay Detail
Functional
CHEMBL783703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamine
65
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 5.70 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284994 | — | — | 2 | 7.36 |
| CHEMBL37714 | — | — | 2 | 7.28 |
| CHEMBL1788361 | — | — | 1 | 7.22 |
| CHEMBL1743855 | — | — | 1 | 7.10 |
| CHEMBL1788366 | — | — | 1 | 7.00 |
| CHEMBL38120 | TAMETRALINE | 2.0 | 2 | 6.82 |
| CHEMBL1743845 | — | — | 1 | 6.77 |
| CHEMBL1788368 | TAMETRALINE HYDROCHLORIDE | -1.0 | 1 | 6.68 |
| CHEMBL1743844 | — | — | 1 | 6.66 |
| CHEMBL809 | SERTRALINE | 4.0 | 2 | 6.50 |
| CHEMBL1743860 | — | — | 1 | 6.42 |
| CHEMBL1743851 | — | — | 1 | 6.40 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 1 | 6.39 |
| CHEMBL36050 | — | — | 2 | 6.31 |
| CHEMBL1709 | SERTRALINE HYDROCHLORIDE | 4.0 | 1 | 6.28 |
| CHEMBL1743854 | — | — | 1 | 6.28 |
| CHEMBL1743859 | — | — | 1 | 6.08 |
| CHEMBL1743868 | — | — | 1 | 6.07 |
| CHEMBL287499 | — | — | 1 | 5.92 |
| CHEMBL1743864 | — | — | 1 | 5.90 |
| CHEMBL1788370 | — | — | 1 | 5.86 |
| CHEMBL36714 | — | — | 2 | 5.85 |
| CHEMBL1788364 | — | — | 1 | 5.82 |
| CHEMBL1743865 | — | — | 1 | 5.80 |
| CHEMBL1743874 | — | — | 1 | 5.77 |
| CHEMBL39354 | — | — | 1 | 5.70 |
| CHEMBL38369 | — | — | 2 | 5.60 |
| CHEMBL1788367 | — | — | 1 | 5.59 |
| CHEMBL39591 | — | — | 1 | 5.58 |
| CHEMBL1743848 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284994 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL37714 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1788361 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1743855 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1788366 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL38120 | TAMETRALINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1743845 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1788368 | TAMETRALINE HYDROCHLORIDE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1743844 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL284994 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL809 | SERTRALINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1743860 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1743851 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL273575 | NOMIFENSINE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL36050 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1709 | SERTRALINE HYDROCHLORIDE | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1743854 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1743859 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1743868 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL287499 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1743864 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL809 | SERTRALINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1788370 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL37714 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL36714 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL38120 | TAMETRALINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1788364 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1743865 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1743874 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL39354 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL38369 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1788367 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL39591 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL36714 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1743848 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1743849 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1743863 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1743846 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1743852 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1788365 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL36260 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL39856 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1743872 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1743857 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1743858 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL290359 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL36050 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL39856 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1743856 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1743847 | — | IC50 | = | 6800.0 | nM | 5.17 |