Cytochrome P450 1A2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P05177. Use UniProt P05177 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P05177 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 1A2
Review this target as Cytochrome P450 1A2, mapped to UniProt P05177. Sequence length is 516 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 1A2 as ChEMBL target CHEMBL3356, mapped to UniProt P05177. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cytochrome P450 1A2 is the right protein anchor across sources, using UniProt P05177 as the stable mapping.
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| Preferred Name | Cytochrome P450 1A2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P05177 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 1A2 |
| UniProt Accession | P05177 |
| Component Type | Protein |
| Sequence Length | 516 aa |
Cytochrome P450 1A2
Review this target as Cytochrome P450 1A2, mapped to UniProt P05177. Sequence length is 516 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5279681 | 9.9 | IC50 | 0.125 | Preclinical |
| CHEMBL4447260 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL283196 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL1223034 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL4456952 | 8.39 | IC50 | 4.1 | Preclinical |
| CHEMBL16073 | 8.31 | IC50 | 4.9 | Approved |
| CHEMBL4282750 | 8.22 | Ki | 6.0 | Preclinical |
| CHEMBL112532 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL279564 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL512079 | 8.05 | IC50 | 9.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,503 | 897 | 5.6 |
| microsome format | 524 | 297 | 5.4 |
| assay format | 217 | 189 | 5.8 |
| cell-based format | 106 | 50 | 6.1 |
| tissue-based format | 44 | 10 | 5.3 |
| cell membrane format | 8 | 45 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 18 | 64 | 5.5 |
| single protein format | 18 | 25 | 5.4 |
| tissue-based format | 5 | 4 | 5.2 |
| cell-based format | 4 | 42 | 6.1 |
| microsome format | 3 | 1 | 6.2 |
| cell membrane format | 1 | 4 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| microsome format | 1 | 0 | — |