Compound Detail

CHEMBL506247

TANNIC ACID

💊 Approved Drug

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💊 Approved Drug

O=C(OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL506247
Name	TANNIC ACID
Phase	Approved
Structure Type	MOL
InChI Key	LRBQNJMCXXYXIU-PPKXGCFTSA-N

Known Names

Asian holly oak nutgall E181 FEMA NO. 3042 Gallotannic acid Gallotannin NSC-656273 NSC-758670 Tannic acid Tannic acid component of depinar Tannic acid component of oc-108 Tannic acid, unspecified Tannicum acidum

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

1701.2

MW (Da)

Drug Information

Molecule Type	Unknown
First Approval	1982
Availability	Discontinued
Chirality	Single Enantiomer

Routes of Administration

Parenteral

Flags

Natural Product

Extended Properties

Molecular Formula	C76H52O46
MW	1701.21

Indications

Gastroenteritis

Activity Summary

IC50 34 meas. best 7.66

Ki 6 meas. best 5.84

EC50 3 meas. best 6.23

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Tyrosine-protein kinase Fyn CHEMBL1841	IC50	7.66	7.66	22.0	1
Unchecked CHEMBL612545	IC50	7.54	6.0625	29.0	8
Tyrosine-protein kinase Lck CHEMBL258	IC50	7.1	7.1	79.0	1
Genome polyprotein CHEMBL5980	IC50	6.89	6.89	130.0	4
Mitogen-activated protein kinase 1 CHEMBL4040	IC50	6.73	6.73	185.0	1
Polyunsaturated fatty acid lipoxygenase ALOX15 CHEMBL4358	IC50	6.57	6.57	268.0	1
Thromboxane-A synthase CHEMBL1835	IC50	6.49	6.49	325.0	1
Aldo-keto reductase family 1 member B1 CHEMBL2622	IC50	6.46	6.46	346.0	1
Mitogen-activated protein kinase 14 CHEMBL260	IC50	6.43	6.43	375.0	1
Replicase polyprotein 1ab CHEMBL4523582	EC50	6.23	6.23	585.0	1
GroEL/GroES CHEMBL4106139	IC50	6.06	6.03	870.0	2
Cytochrome P450 1A2 CHEMBL3356	IC50	6.04	6.04	919.0	1
Solute carrier organic anion transporter family member 1B1 CHEMBL1697668	Ki	5.84	5.84	1460.0	1
Transmembrane protease serine 2 CHEMBL1795140	IC50	5.64	5.64	2310.0	1
Solute carrier organic anion transporter family member 1B1 CHEMBL1697668	IC50	5.58	5.58	2630.3	1
Leukotriene C4 synthase CHEMBL1909043	IC50	5.57	5.57	2715.0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase CHEMBL402	IC50	5.5	5.5	3127.0	1
Solute carrier organic anion transporter family member 1B3 CHEMBL1743121	Ki	5.49	5.49	3230.0	1
HSP60/HSP10 CHEMBL4106131	IC50	5.42	5.42	3800.0	1
Mitogen-activated protein kinase 3 CHEMBL3385	IC50	5.39	5.39	4052.0	1
Solute carrier organic anion transporter family member 1B3 CHEMBL1743121	IC50	5.38	5.38	4168.7	1
Cytochrome P450 2C9 CHEMBL3397	IC50	5.34	5.34	4607.4	1
cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827	IC50	5.33	5.33	4703.0	1
Replicase polyprotein 1a CHEMBL3927	EC50	5.08	5.08	8307.0	1
Carbonic anhydrase CHEMBL1795125	Ki	5.03	5.03	9410.0	1
SARS-CoV-2 CHEMBL4303835	EC50	4.89	4.89	12900.0	1
Replicase polyprotein 1ab CHEMBL4523582	IC50	4.88	4.88	13200.0	1
Carbonic anhydrase 6 CHEMBL3025	Ki	4.75	4.75	17800.0	1
Carbonic anhydrase 2 CHEMBL205	Ki	4.48	4.48	32800.0	1
Thiosulfate sulfurtransferase CHEMBL4295835	IC50	4.41	4.41	39000.0	1
Carbonic anhydrase 1 CHEMBL261	Ki	4.12	4.12	75900.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Tyrosine-protein kinase Fyn	IC50	=	22.0	nM	7.66	DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:...	-
Unchecked	IC50	=	29.0	nM	7.54	Inhibition of H(+)/K(+) ATPase from pig gastric mucosa	1324983
Tyrosine-protein kinase Lck	IC50	=	79.0	nM	7.1	DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:...	-
Genome polyprotein	IC50	=	130.0	nM	6.89	Inhibition of Dengue Virus 1 recombinant NS2B-NS3 protease expressed in Escheric...	34601454
Genome polyprotein	IC50	=	130.0	nM	6.89	Inhibition of Dengue Virus 2 recombinant NS2B-NS3 protease expressed in Escheric...	34601454
Genome polyprotein	IC50	=	130.0	nM	6.89	Inhibition of Dengue Virus 3 recombinant NS2B-NS3 protease expressed in Escheric...	34601454
Genome polyprotein	IC50	=	130.0	nM	6.89	Inhibition of Dengue Virus 4 recombinant NS2B-NS3 protease expressed in Escheric...	34601454
Mitogen-activated protein kinase 1	IC50	=	185.0	nM	6.73	DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: ...	-
Polyunsaturated fatty acid lipoxygenase ALOX15	IC50	=	268.0	nM	6.57	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	-
Unchecked	IC50	=	300.0	nM	6.52	Inhibition of GST (unknown origin) using CDNB as substrate	30040425
Thromboxane-A synthase	IC50	=	325.0	nM	6.49	DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)	-
Aldo-keto reductase family 1 member B1	IC50	=	346.0	nM	6.46	DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde)	-
Mitogen-activated protein kinase 14	IC50	=	375.0	nM	6.43	DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substra...	-
Unchecked	IC50	=	410.0	nM	6.39	Inhibition of K+ dependent pNPPase from pig gastric mucosa	1324983
Replicase polyprotein 1ab	EC50	=	585.0	nM	6.23	Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro e...	37229831
Unchecked	IC50	=	714.0	nM	6.15	DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP...	-
GroEL/GroES	IC50	=	870.0	nM	6.06	Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Esche...	30852084
Cytochrome P450 1A2	IC50	=	919.0	nM	6.04	DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	-
GroEL/GroES	IC50	=	1000.0	nM	6.0	Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Esch...	30852084
Unchecked	IC50	=	1043.0	nM	5.98	DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP...	-

Literature References

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL3885861	Rattus norvegicus	1487
21805983	10.1021/np200011a	Caenorhabditis elegans	13
15646539	10.1016/s0399-8320(04)95062-2	Unchecked	11
15646539	10.1016/s0399-8320(04)95062-2	NON-PROTEIN TARGET	8
1324983	10.1021/np50082a022	Unchecked	4
34601454	10.1016/j.bmc.2021.116415	Genome polyprotein	4
30852084	10.1016/j.bmcl.2019.02.028	GroEL/GroES	4
20014752	10.1021/tx900326k	Hepatotoxicity	3
28478866	10.1016/j.bmc.2017.04.023	Amyloid-beta precursor protein	3
23571415	10.1124/mol.112.084152	Solute carrier organic anion transporter family member 1B1	3
23571415	10.1124/mol.112.084152	Solute carrier organic anion transporter family member 1B3	3
28667872	10.1016/j.ejmech.2017.06.043	Staphylococcus aureus	2
36731248	10.1016/j.bmc.2023.117187	Staphylococcus aureus	2
12039563	10.1016/s0960-894x(02)00245-7	Unchecked	2
28667872	10.1016/j.ejmech.2017.06.043	Salmonella typhimurium	2
28667872	10.1016/j.ejmech.2017.06.043	Pseudomonas aeruginosa	2
23394144	10.1021/jm301558t	Anthrax toxin receptor 2	1
38838547	10.1016/j.ejmech.2024.116548	Amyloid-beta precursor protein	1
21669522	10.1016/j.bmcl.2011.05.071	Carbonic anhydrase 1	1
1710653	10.1021/np50073a012	Human immunodeficiency virus type 1 reverse transcriptase	1

Data from ChEMBL 36 via Core Engine