Assay Detail
Binding
CHEMBL1909116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.79 | 7.85 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 2 | 7.85 |
| CHEMBL808 | ECONAZOLE | 4.0 | 2 | 7.54 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 2 | 7.19 |
| CHEMBL163 | RITONAVIR | 4.0 | 2 | 7.12 |
| CHEMBL1221 | SULCONAZOLE | 4.0 | 2 | 6.74 |
| CHEMBL941 | IMATINIB | 4.0 | 2 | 6.70 |
| CHEMBL91 | MICONAZOLE | 4.0 | 2 | 6.58 |
| CHEMBL506247 | TANNIC ACID | 4.0 | 2 | 6.49 |
| CHEMBL10 | SB-203580 | — | 2 | 6.31 |
| CHEMBL14192 | BENZYLIMIDAZOLE | — | 2 | 6.22 |
| CHEMBL1262 | OXICONAZOLE | 4.0 | 2 | 6.21 |
| CHEMBL1201469 | GRAMICIDIN | 4.0 | 2 | 6.11 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 6.04 |
| CHEMBL787 | MONTELUKAST | 4.0 | 2 | 5.82 |
| CHEMBL460291 | LACIDIPINE | 3.0 | 2 | 5.77 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 5.74 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 2 | 5.73 |
| CHEMBL159 | VINBLASTINE | 4.0 | 2 | 5.73 |
| CHEMBL1385840 | ERGOCORNINE | — | 2 | 5.70 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 5.67 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 2 | 5.66 |
| CHEMBL434063 | — | — | 2 | 5.53 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 2 | 5.53 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 2 | 5.51 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 5.51 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 5.51 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 2 | 5.45 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 2 | 5.42 |
| CHEMBL428 | TROVAFLOXACIN | 4.0 | 2 | 5.39 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 2 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL163 | RITONAVIR | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1221 | SULCONAZOLE | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL941 | IMATINIB | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL506247 | TANNIC ACID | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL10 | SB-203580 | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL14192 | BENZYLIMIDAZOLE | IC50 | = | 602.0 | nM | 6.22 |
| CHEMBL1262 | OXICONAZOLE | IC50 | = | 617.4 | nM | 6.21 |
| CHEMBL1201469 | GRAMICIDIN | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 916.0 | nM | 6.04 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 1525.0 | nM | 5.82 |
| CHEMBL460291 | LACIDIPINE | IC50 | = | 1694.0 | nM | 5.77 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 1851.0 | nM | 5.73 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1385840 | ERGOCORNINE | IC50 | = | 1993.0 | nM | 5.70 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 2165.0 | nM | 5.67 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 2182.0 | nM | 5.66 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 2966.0 | nM | 5.53 |
| CHEMBL434063 | — | IC50 | = | 2953.0 | nM | 5.53 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 3087.0 | nM | 5.51 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 3064.0 | nM | 5.51 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 3059.4 | nM | 5.51 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL428 | TROVAFLOXACIN | IC50 | = | 4023.0 | nM | 5.39 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 4359.0 | nM | 5.36 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | IC50 | = | 4927.0 | nM | 5.31 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | IC50 | = | 6452.0 | nM | 5.19 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 6727.0 | nM | 5.17 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 6760.8 | nM | 5.17 |
| CHEMBL44 | GENISTEIN | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 9347.0 | nM | 5.03 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 18594.0 | nM | 4.73 |
| CHEMBL421 | SULFASALAZINE | IC50 | = | 19639.0 | nM | 4.71 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 21110.0 | nM | 4.68 |
| CHEMBL195437 | 4-OCTYLPHENOL | IC50 | = | 66049.0 | nM | 4.18 |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - |