Thromboxane-A synthase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Thromboxane-A synthase shows approved-linked disease relevance led by Recurrent thrombophlebitis. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P24557. Start with Recurrent thrombophlebitis, then reuse UniProt P24557 as the stable protein anchor across project notes and exports.
Start with Recurrent thrombophlebitis, then reuse UniProt P24557 as the stable protein anchor across project notes and exports.
Thromboxane-A synthase shows approved-linked disease relevance led by Recurrent thrombophlebitis. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Recurrent thrombophlebitis because it currently carries approved-linked support. Linked drugs include PICOTAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyThromboxane-A synthase
Review this target as Thromboxane-A synthase, mapped to UniProt P24557. Sequence length is 533 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thromboxane-A synthase as ChEMBL target CHEMBL1835, mapped to UniProt P24557. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Thromboxane-A synthase is the right protein anchor across sources, using UniProt P24557 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Recurrent thrombophlebitis is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Thromboxane-A synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P24557 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thromboxane-A synthase |
| UniProt Accession | P24557 |
| Component Type | Protein |
| Sequence Length | 533 aa |
Thromboxane-A synthase
Review this target as Thromboxane-A synthase, mapped to UniProt P24557. Sequence length is 533 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Thromboxane-A synthase shows approved-linked disease relevance led by Recurrent thrombophlebitis. 2 more disease programs remain visible in the same review block.
Start review with Recurrent thrombophlebitis because it currently carries approved-linked support. Linked drugs include PICOTAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL26820 | 9.05 | IC50 | 0.89 | Preclinical |
| CHEMBL28196 | 9.05 | IC50 | 0.9 | Clinical |
| CHEMBL117233 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL136762 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL137402 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL165575 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL338420 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL435590 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL116975 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL136738 | 8.82 | IC50 | 1.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 62 | 239 | 7.0 |
| assay format | 60 | 458 | 7.2 |
| tissue-based format | 6 | 67 | 5.8 |
| cell-free format | 5 | 13 | 7.1 |
| cell-based format | 3 | 0 | — |
| microsome format | 2 | 6 | 7.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 31 | 58 | 6.5 |
| organism-based format | 28 | 0 | — |
| microsome format | 6 | 30 | 6.7 |
| cell-free format | 4 | 17 | 6.0 |
| tissue-based format | 3 | 25 | 6.9 |