Tyrosine-protein kinase Fyn · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Tyrosine-protein kinase Fyn shows clinical signal disease relevance led by cancer. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P06241. Start with cancer, then reuse UniProt P06241 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt P06241 as the stable protein anchor across project notes and exports.
Tyrosine-protein kinase Fyn shows clinical signal disease relevance led by cancer. 1 linked drug remains visible in the same block.
Start review with cancer because it currently carries clinical signal support. Linked drugs include JNJ-26483327. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTyrosine-protein kinase Fyn
Review this target as Tyrosine-protein kinase Fyn, mapped to UniProt P06241. Sequence length is 537 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase Fyn as ChEMBL target CHEMBL1841, mapped to UniProt P06241. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Tyrosine-protein kinase Fyn is the right protein anchor across sources, using UniProt P06241 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Tyrosine-protein kinase Fyn |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P06241 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase Fyn |
| UniProt Accession | P06241 |
| Component Type | Protein |
| Sequence Length | 537 aa |
Tyrosine-protein kinase Fyn
Review this target as Tyrosine-protein kinase Fyn, mapped to UniProt P06241. Sequence length is 537 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tyrosine-protein kinase Fyn shows clinical signal disease relevance led by cancer.
Start review with cancer because it currently carries clinical signal support. Linked drugs include JNJ-26483327. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5416410 | 9.7 | IC50 | 0.2 | Approved |
| CHEMBL45177 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL1969102 | 9.5 | Ki | 0.3162 | Preclinical |
| CHEMBL1171837 | 9.44 | IC50 | 0.36 | Approved |
| CHEMBL1994938 | 9.4 | Ki | 0.3981 | Preclinical |
| CHEMBL249097 | 9.4 | Kd | 0.4 | Preclinical |
| CHEMBL1982476 | 9.2 | Ki | 0.631 | Preclinical |
| CHEMBL5416410 | 9.1 | Kd | 0.79 | Approved |
| CHEMBL364623 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL515414 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 465 | 893 | 5.9 |
| cell-based format | 66 | 73 | 5.5 |
| assay format | 63 | 21 | 6.6 |
| subcellular format | 26 | 28 | 6.6 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 237 | 6.5 |
| cell-based format | 3 | 4 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 1 | 6.8 |
| assay format | 1 | 0 | — |
| cell-based format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |