Assay Detail
Binding
CHEMBL4392934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 5.24 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200712 | EVANS BLUE | 4.0 | 1 | 7.06 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 6.54 |
| CHEMBL253570 | GOSSYPETIN | — | 1 | 6.41 |
| CHEMBL1516388 | — | — | 1 | 6.37 |
| CHEMBL704 | MESALAMINE | 4.0 | 1 | 6.31 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 6.24 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.24 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.23 |
| CHEMBL3989697 | RIBOFLAVIN 5'-PHOSPHATE SODIUM | 4.0 | 1 | 6.11 |
| CHEMBL506247 | TANNIC ACID | 4.0 | 1 | 6.00 |
| CHEMBL1360563 | HEMATEIN | — | 1 | 5.92 |
| CHEMBL5483017 | — | — | 1 | 5.92 |
| CHEMBL4448756 | — | — | 1 | 5.70 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 1 | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.62 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.60 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.54 |
| CHEMBL1325592 | PROTOPORPHYRIN | -1.0 | 1 | 5.52 |
| CHEMBL550495 | METHYLENE BLUE | 4.0 | 1 | 5.48 |
| CHEMBL294264 | PURPURIN | — | 1 | 5.40 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 1 | 5.33 |
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 5.33 |
| CHEMBL1265 | ADAPALENE | 4.0 | 1 | 5.29 |
| CHEMBL28626 | MORIN | — | 1 | 5.28 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 5.21 |
| CHEMBL220190 | ASCORBYL PALMITATE | -1.0 | 1 | 5.07 |
| CHEMBL78764 | — | — | 1 | 5.05 |
| CHEMBL2003538 | CETYLPYRIDINIUM CHLORIDE | 3.0 | 1 | 5.05 |
| CHEMBL5314343 | — | — | 1 | 4.92 |
| CHEMBL290106 | BITHIONOL | 4.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200712 | EVANS BLUE | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL253570 | GOSSYPETIN | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1516388 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL704 | MESALAMINE | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3989697 | RIBOFLAVIN 5'-PHOSPHATE SODIUM | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL506247 | TANNIC ACID | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1360563 | HEMATEIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5483017 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4448756 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL590 | MENADIONE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL140 | CURCUMIN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1325592 | PROTOPORPHYRIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL550495 | METHYLENE BLUE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL294264 | PURPURIN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1265 | ADAPALENE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL28626 | MORIN | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL220190 | ASCORBYL PALMITATE | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2003538 | CETYLPYRIDINIUM CHLORIDE | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL78764 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5314343 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL64894 | GENTIAN VIOLET | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL265502 | SURAMIN | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL129177 | HARMALOL | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1236460 | THIOSTREPTON | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL15594 | ARACHIDONIC ACID | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1534 | RIBOFLAVIN | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL38 | TRETINOIN | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL6067487 | IVERMECTIN | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL153062 | 4-NONYLPHENOL | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1042 | CHOLECALCIFEROL | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1630577 | ABAMECTIN COMPONENT B1A | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1879202 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1536 | ERGOCALCIFEROL | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL33845 | DICHLOROPHEN | IC50 | = | 66000.0 | nM | 4.18 |