GroEL/GroES · PROTEIN COMPLEX · Escherichia coli
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As of 2026-09-13Protein identity stays anchored to UniProt Q548M1. Use UniProt Q548M1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q548M1 as the stable identity anchor, then attach disease evidence before program review.
Chaperonin GroEL
Review this target as GroEL/GroES, mapped to UniProt Q548M1. ChEMBL maps the protein component as Chaperonin GroEL. Sequence length is 548 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats GroEL/GroES as ChEMBL target CHEMBL4106139, mapped to UniProt Q548M1. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether GroEL/GroES is the right protein anchor across sources, using UniProt Q548M1 as the stable mapping.
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| Preferred Name | GroEL/GroES |
| Target Type | PROTEIN COMPLEX |
| Organism | Escherichia coli |
| UniProt | Q548M1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Chaperonin GroEL |
| UniProt Accession | Q548M1 |
| Component Type | Protein |
| Sequence Length | 548 aa |
Chaperonin GroEL
Review this target as GroEL/GroES, mapped to UniProt Q548M1. ChEMBL maps the protein component as Chaperonin GroEL. Sequence length is 548 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1200712 | 7.41 | IC50 | 39.0 | Approved |
| CHEMBL3115908 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL3986320 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL3115913 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL295316 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL297453 | 6.44 | IC50 | 360.0 | Clinical |
| CHEMBL253570 | 6.41 | IC50 | 390.0 | Preclinical |
| CHEMBL1516388 | 6.37 | IC50 | 430.0 | Preclinical |
| CHEMBL3115909 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL704 | 6.31 | IC50 | 490.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 14 | 209 | 5.0 |
| protein complex format | 6 | 31 | 4.8 |
| cell-based format | 5 | 21 | 5.3 |