Assay Detail
Binding
CHEMBL1909201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.91 | 7.22 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | — | 2 | 7.22 |
| CHEMBL115769 | — | — | 2 | 7.12 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 7.06 |
| CHEMBL10 | SB-203580 | — | 2 | 6.80 |
| CHEMBL1909071 | — | — | 2 | 6.73 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 6.50 |
| CHEMBL1909050 | — | — | 2 | 6.48 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 2 | 6.45 |
| CHEMBL86754 | IODOQUINOL | 2.0 | 2 | 6.44 |
| CHEMBL506247 | TANNIC ACID | 4.0 | 2 | 6.43 |
| CHEMBL437002 | — | — | 2 | 6.27 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 2 | 6.19 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 2 | 6.18 |
| CHEMBL1909051 | — | — | 2 | 6.15 |
| CHEMBL24944 | TRIBROMSALAN | 4.0 | 2 | 6.15 |
| CHEMBL1909049 | — | — | 2 | 6.13 |
| CHEMBL1909048 | — | — | 2 | 6.08 |
| CHEMBL787 | MONTELUKAST | 4.0 | 2 | 6.07 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 2 | 5.91 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | 4.0 | 2 | 5.66 |
| CHEMBL1909068 | — | — | 2 | 5.64 |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 2 | 5.60 |
| CHEMBL37161 | FENBENDAZOLE | 2.0 | 2 | 5.50 |
| CHEMBL1909070 | NAFENOPIN | 2.0 | 2 | 5.43 |
| CHEMBL141343 | — | — | 2 | 5.25 |
| CHEMBL1630578 | TIRILAZAD | 3.0 | 2 | 5.13 |
| CHEMBL195437 | 4-OCTYLPHENOL | — | 2 | 4.82 |
| CHEMBL584 | NELFINAVIR | 4.0 | 2 | 4.74 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 2 | 4.48 |
| CHEMBL1873703 | DIELDRIN | 2.0 | 2 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | = | 60.6 | nM | 7.22 |
| CHEMBL115769 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL10 | SB-203580 | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL1909071 | — | IC50 | = | 186.8 | nM | 6.73 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL1909050 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL86754 | IODOQUINOL | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL506247 | TANNIC ACID | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL437002 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL24944 | TRIBROMSALAN | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL1909051 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL1909049 | — | IC50 | = | 746.0 | nM | 6.13 |
| CHEMBL1909048 | — | IC50 | = | 833.0 | nM | 6.08 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 1235.0 | nM | 5.91 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | IC50 | = | 2176.0 | nM | 5.66 |
| CHEMBL1909068 | — | IC50 | = | 2272.0 | nM | 5.64 |
| CHEMBL547 | ISOTRETINOIN | IC50 | = | 2529.0 | nM | 5.60 |
| CHEMBL37161 | FENBENDAZOLE | IC50 | = | 3188.0 | nM | 5.50 |
| CHEMBL1909070 | NAFENOPIN | IC50 | = | 3740.5 | nM | 5.43 |
| CHEMBL141343 | — | IC50 | = | 5596.0 | nM | 5.25 |
| CHEMBL1630578 | TIRILAZAD | IC50 | = | 7406.0 | nM | 5.13 |
| CHEMBL195437 | 4-OCTYLPHENOL | IC50 | = | 15016.0 | nM | 4.82 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 18224.0 | nM | 4.74 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 32903.0 | nM | 4.48 |
| CHEMBL1873703 | DIELDRIN | IC50 | = | 43193.0 | nM | 4.37 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 83061.0 | nM | 4.08 |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | Ki | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | IC50 | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | IC50 | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | Ki | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | Ki | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | IC50 | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | Ki | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | IC50 | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | Ki | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | IC50 | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL21731 | MAPROTILINE | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | - | — | - |