Compound Detail
CHEMBL37161
FENBENDAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL37161 |
| Name | FENBENDAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | HDDSHPAODJUKPD-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
8
Targets
20
Activities
2
Assay Types
9
PK Parameters
20
Publications
10
Known Names
1
Indications
2
Mechanisms
Molecular Properties
299.4
MW (Da)
3.89
ALogP
4
HBA
2
HBD
67.0
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Tubulin beta chain binding agent | BINDING AGENT | Tubulin beta chain | ✓ | ✓ |
| Tubulin beta chain binding agent | BINDING AGENT | Tubulin beta chain | ✓ | ✓ |
Indications
Helminthiasis
ATC Classification
P02CA06
fenbendazole
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTHELMINTICS
Activity Summary
IC50 15 meas. best 9.0
EC50 5 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 9.0 | 7.11 | 1.0 | 12 |
| Giardia intestinalis CHEMBL612652 | IC50 | 7.25 | 7.25 | 56.0 | 1 |
| Nippostrongylus brasiliensis CHEMBL613822 | EC50 | 6.92 | 6.92 | 120.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 6.04 | 6.04 | 910.0 | 1 |
| PC-3M CHEMBL4296484 | EC50 | 5.58 | 5.58 | 2600.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 5.5 | 5.5 | 3188.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL2146315 | EC50 | 5.4 | 5.4 | 4000.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL3401 | EC50 | 5.0 | 5.0 | 10000.0 | 1 |
| Plasmodium yoelii yoelii CHEMBL612328 | IC50 | 4.52 | 4.52 | 30000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 310.0 | ng.hr.mL-1 | Sus scrofa |
| AUC | 35000.0 | ng.hr.mL-1 | Sus scrofa |
| AUC | 12730.0 | ng.hr.mL-1 | Sus scrofa |
| Cmax | 167.02 | nM | Sus scrofa |
| Cmax | 3641.1 | nM | Sus scrofa |
| Cmax | 1269.37 | nM | Sus scrofa |
| Tmax | 5.4 | hr | Sus scrofa |
| Tmax | 17.0 | hr | Sus scrofa |
| Tmax | 34.0 | hr | Sus scrofa |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine